Knockdown of NLRC5 inhibits renal fibroblast activation via modulating TGF‐&bgr;1/Smad signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.045
Abstract: &NA; NLRC5, the largest member of the Nucleotide‐binding domain and leucine‐rich repeat (NLR) protein family, is recently proven to be a critical modulator in fibrogenesis. However, the role of NLRC5 in renal fibrosis remains unknown.… read more here.
Keywords: bgr; knockdown nlrc5; renal fibroblast; tgf bgr ... See more keywords
Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02479-2
Abstract: The association between kidney stone disease and renal fibrosis has been widely explored in recent years but its underlying mechanisms remain far from complete understanding. Using label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS), this study identified 23… read more here.
Keywords: renal fibroblast; macrophages exposed; calcium oxalate; activation ... See more keywords
TRPM7 contributes to TGF-ß signaling in renal fibroblast
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735155
Abstract: Mammalian transient receptor potential melastatin (TRPM), the non-selective cation channel subfamily, has eight members and is extensively expressed in excitable and non-excitable cells where they perform diverse functions, including sensory transduction, magnesium reabsorption, cell adhesion,… read more here.
Keywords: fibroblast; trpm7; expression; physiology ... See more keywords