Asiaticoside inhibits renal fibrosis development by regulating the miR-142-5p/ACTN4 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2110
Abstract: Renal fibrosis results in the progressive renal dysfunction and leads to chronic kidney disease (CKD) and ultimately end-stage renal disease. Asiaticoside was reported to regulate synaptopodin, desmin, nephrin and podocin levels in adriamycin-induced nephropathy of… read more here.
Keywords: 142 actn4; regulating mir; mir 142; actn4 axis ... See more keywords
PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29057
Abstract: Renal fibrosis, the ultimate common pathway of progressive nephropathy, is characterized by excess accumulation and deposition of extracellular matrix (ECM) within the renal interstitium and glomeruli, finally resulting in end‐stage kidney failure. TGFβ1 is not… read more here.
Keywords: fibrosis; vitro vivo; inhibiting fak; fak akt ... See more keywords
Editorial for “Quantitative Magnetization Transfer Detects Renal Fibrosis in Murine Kidneys With Renal Artery Stenosis”
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27388
Abstract: Renal fibrosis may start and silently progress for a long time before there are indications of kidney disease. Loss of peritubular capillaries and impaired oxygen diffusion due to fibrosis result in hypoxia and excessive inflammatory… read more here.
Keywords: renal artery; magnetization transfer; fibrosis; renal fibrosis ... See more keywords
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7599
Abstract: Quercetin is a widely distributed, bioactive flavonoid compound, which displays potential to inhibit fibrosis in several diseases. The purpose of our study was to determine the effect of quercetin treatment on renal fibrosis and investigate… read more here.
Keywords: renal fibrosis; quercetin inhibits; egfr signaling; tubular epithelial ... See more keywords
Role of Aldosterone in Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_15
Abstract: Aldosterone is a mineralocorticoid hormone, as its main renal effect has been considered as electrolyte and water homeostasis in the distal tubule, thus maintaining blood pressure and extracellular fluid homeostasis through the activation of mineralocorticoid… read more here.
Keywords: fibrosis; aldosterone; renal fibrosis; factor ... See more keywords
TGF-β/Smad and Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_16
Abstract: Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the major pathological mechanism of chronic kidney disease (CKD).… read more here.
Keywords: fibrosis; tgf smad; disease; renal fibrosis ... See more keywords
Mitochondria and Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_25
Abstract: Mitochondria are important organelles in eukaryotic cells and perform a variety of biosynthetic and metabolic functions. Many human diseases are closely related to mitochondrial dysfunction. Kidney is an organ with high-energy requirements, which is distributed… read more here.
Keywords: fibrosis; renal fibrosis; mitochondria renal; biology ... See more keywords
Lipid Metabolism Disorder and Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_26
Abstract: Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this chapter, we will discuss the general promises of the… read more here.
Keywords: fibrosis; disorder renal; renal fibrosis; metabolism disorder ... See more keywords
Cell Apoptosis and Autophagy in Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_28
Abstract: Renal fibrosis is the final common pathway of all chronic kidney diseases progressing to end-stage renal diseases. Autophagy, a highly conserved lysosomal degradation pathway, plays important roles in maintaining cellular homeostasis in all major types… read more here.
Keywords: fibrosis; kidney diseases; cell apoptosis; renal fibrosis ... See more keywords
Current Opinion for Hypertension in Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_3
Abstract: Arterial hypertension remains to be a serious problem with considerable morbidity and mortality worldwide in the present age. Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial infarction, renal failure, and… read more here.
Keywords: fibrosis; renal fibrosis; opinion hypertension; hypertension ... See more keywords
A Glimpse of the Mechanisms Related to Renal Fibrosis in Diabetic Nephropathy.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_4
Abstract: Diabetic nephropathy (DN) is a common kidney disease in people with diabetes, which is also a serious microvascular complication of diabetes and the main cause of end-stage renal disease (ESRD) in developed and developing countries.… read more here.
Keywords: glimpse mechanisms; mechanisms related; fibrosis; renal fibrosis ... See more keywords