Macrophage Derived Galectin‐3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202504032
Abstract: Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease. Renal fibrosis represents the final pathological outcome of most chronic… read more here.
Keywords: fibrosis; renal fibrosis; kidney disease; diabetic kidney ... See more keywords
Asiaticoside inhibits renal fibrosis development by regulating the miR-142-5p/ACTN4 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2110
Abstract: Renal fibrosis results in the progressive renal dysfunction and leads to chronic kidney disease (CKD) and ultimately end-stage renal disease. Asiaticoside was reported to regulate synaptopodin, desmin, nephrin and podocin levels in adriamycin-induced nephropathy of… read more here.
Keywords: 142 actn4; regulating mir; mir 142; actn4 axis ... See more keywords
miR‐542‐5p targets GREM1 to affect the progression of renal fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23818
Abstract: Renal fibrosis (RF) is a typical pathological presentation of end‐stage chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD). However, the precise regulatory mechanisms governing this re‐expression process remain unclear. Differentially expressed microRNAs… read more here.
Keywords: fibrosis; renal fibrosis; progression; mir 542 ... See more keywords
PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29057
Abstract: Renal fibrosis, the ultimate common pathway of progressive nephropathy, is characterized by excess accumulation and deposition of extracellular matrix (ECM) within the renal interstitium and glomeruli, finally resulting in end‐stage kidney failure. TGFβ1 is not… read more here.
Keywords: fibrosis; vitro vivo; inhibiting fak; fak akt ... See more keywords
Editorial for “Quantitative Magnetization Transfer Detects Renal Fibrosis in Murine Kidneys With Renal Artery Stenosis”
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27388
Abstract: Renal fibrosis may start and silently progress for a long time before there are indications of kidney disease. Loss of peritubular capillaries and impaired oxygen diffusion due to fibrosis result in hypoxia and excessive inflammatory… read more here.
Keywords: renal artery; magnetization transfer; fibrosis; renal fibrosis ... See more keywords
Crocin Attenuates Nrf2/GPX4 Mediated Ferroptosis in Obstructive Nephropathy by Selectively Targeting MKK4
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.70092
Abstract: Renal fibrosis is a critical pathogenesis of chronic kidney disease (CKD). Crocin, an active compound derived from saffron ( Crocus sativus L.), exhibits potent antioxidant and renal protection properties. However, the effects of crocin on… read more here.
Keywords: crocin; mkk4; renal fibrosis; ferroptosis ... See more keywords
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7599
Abstract: Quercetin is a widely distributed, bioactive flavonoid compound, which displays potential to inhibit fibrosis in several diseases. The purpose of our study was to determine the effect of quercetin treatment on renal fibrosis and investigate… read more here.
Keywords: renal fibrosis; quercetin inhibits; egfr signaling; tubular epithelial ... See more keywords
Emodin Inhibits AIM2 Inflammasome Activation via Modulating K27‐Linked Polyubiquitination to Attenuate Renal Fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8390
Abstract: Chronic kidney diseases (CKD) is a serious threat to people's health with renal fibrosis as the major pathological feature. The absent in melanoma 2 (AIM2) has recently been proposed to play a critical role in… read more here.
Keywords: emodin; fibrosis; renal fibrosis; aim2 inflammasome ... See more keywords
Chronic Exposure to an Environmentally Relevant Mixture of Endocrine Disruptors Alters Nuclear Phenotype and Induces Renal Fibrosis in Rats
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DOI: 10.1002/tox.24502
Abstract: The exposome is considered an assessment of environmental exposure and associated biological responses over an individual's lifetime. Endocrine disruptors chemicals (EDCs), an important component of such exposures, exert adverse effects on human health. The kidneys… read more here.
Keywords: mix; renal fibrosis; edcs mix; mixture ... See more keywords
Role of Aldosterone in Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_15
Abstract: Aldosterone is a mineralocorticoid hormone, as its main renal effect has been considered as electrolyte and water homeostasis in the distal tubule, thus maintaining blood pressure and extracellular fluid homeostasis through the activation of mineralocorticoid… read more here.
Keywords: fibrosis; aldosterone; renal fibrosis; factor ... See more keywords
TGF-β/Smad and Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_16
Abstract: Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the major pathological mechanism of chronic kidney disease (CKD).… read more here.
Keywords: fibrosis; tgf smad; disease; renal fibrosis ... See more keywords