Effect of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intravenous Rivipansel
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.842
Abstract: Two studies evaluated the effects of renal and hepatic impairment on pharmacokinetics and safety of rivipansel (NCT02813798, NCT02871570). A single intravenous 840‐mg rivipansel dose was administered to subjects with renal impairment or normal renal function… read more here.
Keywords: rivipansel; renal hepatic; hepatic impairment; impairment pharmacokinetics ... See more keywords
Renal‐hepatic‐pancreatic dysplasia type 2: Perinatal lethal condition or a multisystemic disorder with variable expressivity
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2135
Abstract: Renal‐hepatic‐pancreatic dysplasia type 2 (RHPD2) is a rare condition that has been described in the literature disproportionately in perinatal losses. The main features of liver and kidney involvement are well described, with cardiac malformations and… read more here.
Keywords: hepatic pancreatic; pancreatic dysplasia; renal hepatic; dysplasia type ... See more keywords
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00009
Abstract: Recently developed high-throughput in vitro assays in combination with computational models could provide alternatives to animal testing. The purpose of the present study was to model the plasma, hepatic, and renal pharmacokinetics of approximately 150… read more here.
Keywords: based pharmacokinetic; renal hepatic; physiologically based; industrial chemicals ... See more keywords
Renal-Hepatic-Pancreatic Dysplasia: An Ultra-Rare Ciliopathy with a Novel NPHP3 Genotype.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pediatric genetics"
DOI: 10.1055/s-0039-1696974
Abstract: Renal-hepatic-pancreatic dysplasia-1 (RHPD1) is an ultra-rare genetic disorder with a high mortality. It is caused by biallelic pathogenic variants in NPHP3 , which encode nephrocytin, an important component of the ciliary protein complex. The NPHP3… read more here.
Keywords: renal hepatic; ultra rare; pancreatic dysplasia; hepatic pancreatic ... See more keywords
G588(P) Transient renal and hepatic dysfunction in severe profound hypothyroidism
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-rcpch.569
Abstract: Introduction Thyroxine plays a significant role in hepatic and renal physiology and thyroid dysfunction can therefore produce a wide range of metabolic disturbances. We report two severe hypothyroid paediatric patients presenting with hepatic and renal… read more here.
Keywords: hypothyroidism; hepatic renal; renal hepatic; dysfunction ... See more keywords
Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5633-1
Abstract: BackgroundSeveral subunits of the SWI/SNF chromatin remodeling complex are implicated in both cancer and neurodevelopmental disorders (NDD). Though there is no clinical evidence for an increased tumor risk in individuals with NDDs due to germline… read more here.
Keywords: hepatic angiomyolipomas; renal hepatic; dissecting tsc2; tumor ... See more keywords
Alectinib Induced Regression of Renal and Hepatic Cysts Caused by Crizotinib
Sign Up to like & getrecommendations! Published in 2020 at "International Medical Case Reports Journal"
DOI: 10.2147/imcrj.s229080
Abstract: Background Crizotinib is the first tyrosine kinase inhibitor approved for the treatment of anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC). An increased incidence of renal cysts has been described during the crizotinib… read more here.
Keywords: renal hepatic; hepatic cysts; treatment; caused crizotinib ... See more keywords
A pathogenic variant of TULP3 causes renal and hepatic fibrocystic disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1021037
Abstract: Patient variants in Tubby Like Protein-3 (TULP3) have recently been associated with progressive fibrocystic disease in tissues and organs. TULP3 is a ciliary trafficking protein that links membrane-associated proteins to the intraflagellar transport complex A.… read more here.
Keywords: pathogenic variant; fibrocystic disease; disease; renal hepatic ... See more keywords
Anticancer Dose Adjustment for Patients with Renal and Hepatic Dysfunction: From Scientific Evidence to Clinical Application
Sign Up to like & getrecommendations! Published in 2017 at "Scientia Pharmaceutica"
DOI: 10.3390/scipharm85010008
Abstract: Most anticancer agents exhibit a narrow therapeutic index, i.e., a small change in plasma concentrations can lead to a less efficacious treatment or an unacceptable degree of toxicity. This study aimed at providing health professionals… read more here.
Keywords: renal hepatic; patients renal; dose adjustment; anticancer ... See more keywords
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Medical Journal"
DOI: 10.4103/0366-6999.220310
Abstract: To the Editor: Tuberous sclerosis complex (TSC), a rare autosomal dominant and variable penetrance, affects about 10 in every 100,000 people.[1] In general, it is described as a clinical triad of adenomas, mental disorders, and… read more here.
Keywords: associated renal; tuberous sclerosis; pulmonary lymphangiomyomatosis; renal hepatic ... See more keywords
Investigation of in vivo protective effect of orally administered vitamin E and selenium against gentamicininduced renal and hepatic toxicity
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v18i7.10
Abstract: Purpose: To investigate the protective effect of vitamin E (Vit E) and selenium (Se) combination against gentamycin (GM)-induced renal and hepatic toxicity in rats. Methods: Forty-eight male Wistar albino rats were administrated GM at a… read more here.
Keywords: renal hepatic; toxicity; hepatic toxicity; vitamin ... See more keywords