Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Pritelivir and Its Metabolites
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DOI: 10.1002/cpdd.1469
Abstract: Two trials were performed to evaluate the effect of renal and hepatic impairment on the pharmacokinetics of pritelivir and its metabolites. The renal impairment trial included subjects with mild, moderate, and severe impairment, while the… read more here.
Keywords: effect; hepatic impairment; renal impairment; impairment ... See more keywords
Effect of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intravenous Rivipansel
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.842
Abstract: Two studies evaluated the effects of renal and hepatic impairment on pharmacokinetics and safety of rivipansel (NCT02813798, NCT02871570). A single intravenous 840‐mg rivipansel dose was administered to subjects with renal impairment or normal renal function… read more here.
Keywords: rivipansel; renal hepatic; hepatic impairment; impairment pharmacokinetics ... See more keywords
Renal‐hepatic‐pancreatic dysplasia type 2: Perinatal lethal condition or a multisystemic disorder with variable expressivity
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2135
Abstract: Renal‐hepatic‐pancreatic dysplasia type 2 (RHPD2) is a rare condition that has been described in the literature disproportionately in perinatal losses. The main features of liver and kidney involvement are well described, with cardiac malformations and… read more here.
Keywords: hepatic pancreatic; pancreatic dysplasia; renal hepatic; dysplasia type ... See more keywords
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00009
Abstract: Recently developed high-throughput in vitro assays in combination with computational models could provide alternatives to animal testing. The purpose of the present study was to model the plasma, hepatic, and renal pharmacokinetics of approximately 150… read more here.
Keywords: based pharmacokinetic; renal hepatic; physiologically based; industrial chemicals ... See more keywords
Renal-Hepatic-Pancreatic Dysplasia: An Ultra-Rare Ciliopathy with a Novel NPHP3 Genotype.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pediatric genetics"
DOI: 10.1055/s-0039-1696974
Abstract: Renal-hepatic-pancreatic dysplasia-1 (RHPD1) is an ultra-rare genetic disorder with a high mortality. It is caused by biallelic pathogenic variants in NPHP3 , which encode nephrocytin, an important component of the ciliary protein complex. The NPHP3… read more here.
Keywords: renal hepatic; ultra rare; pancreatic dysplasia; hepatic pancreatic ... See more keywords
G588(P) Transient renal and hepatic dysfunction in severe profound hypothyroidism
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-rcpch.569
Abstract: Introduction Thyroxine plays a significant role in hepatic and renal physiology and thyroid dysfunction can therefore produce a wide range of metabolic disturbances. We report two severe hypothyroid paediatric patients presenting with hepatic and renal… read more here.
Keywords: hypothyroidism; hepatic renal; renal hepatic; dysfunction ... See more keywords
Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5633-1
Abstract: BackgroundSeveral subunits of the SWI/SNF chromatin remodeling complex are implicated in both cancer and neurodevelopmental disorders (NDD). Though there is no clinical evidence for an increased tumor risk in individuals with NDDs due to germline… read more here.
Keywords: hepatic angiomyolipomas; renal hepatic; dissecting tsc2; tumor ... See more keywords
Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice
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DOI: 10.1371/journal.pone.0335906
Abstract: The kynurenine pathway (KP) is the canonical route by which tryptophan is metabolised, almost all of which occurs in the liver, with significant expression of its enzymes also known in the kidney. We generated two… read more here.
Keywords: kynurenine pathway; acid; function preserved; renal hepatic ... See more keywords
Alectinib Induced Regression of Renal and Hepatic Cysts Caused by Crizotinib
Sign Up to like & getrecommendations! Published in 2020 at "International Medical Case Reports Journal"
DOI: 10.2147/imcrj.s229080
Abstract: Background Crizotinib is the first tyrosine kinase inhibitor approved for the treatment of anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC). An increased incidence of renal cysts has been described during the crizotinib… read more here.
Keywords: renal hepatic; hepatic cysts; treatment; caused crizotinib ... See more keywords
Unveiling the Interplay: Antioxidant Enzyme Polymorphisms and Oxidative Stress in Preterm Neonatal Renal and Hepatic Functions.
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DOI: 10.2174/0113892002328584240923095216
Abstract: AIMS To explore the relationship between oxidative stress biomarkers and the occurrence of acute kidney injury (AKI) alongside notable liver function disturbances in preterm neonates. BACKGROUND Given the immaturity of kidneys and incomplete liver development… read more here.
Keywords: stress biomarkers; stress; oxidative stress; enzyme ... See more keywords
A pathogenic variant of TULP3 causes renal and hepatic fibrocystic disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1021037
Abstract: Patient variants in Tubby Like Protein-3 (TULP3) have recently been associated with progressive fibrocystic disease in tissues and organs. TULP3 is a ciliary trafficking protein that links membrane-associated proteins to the intraflagellar transport complex A.… read more here.
Keywords: pathogenic variant; fibrocystic disease; disease; renal hepatic ... See more keywords