Resistant starch from black rice, Oryza sativa L. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7675
Abstract: It has recently been reported that black rice (BR) extract has anti‐obesity, anti‐diabetic, and anti‐osteoporosis effects. It has been shown to reduce obese‐related kidney dysfunction in animal models. This study aimed to investigate the effect… read more here.
Keywords: insulin resistant; renal inflammation; resistant rats; injury ... See more keywords
Arid2-IR promotes NF-κB-mediated renal inflammation by targeting NLRC5 transcription
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03659-9
Abstract: Increasing evidence shows that long non-coding RNAs (lncRNAs) play an important role in a variety of disorders including kidney diseases. It is well recognized that inflammation is the initial step of kidney injury and is… read more here.
Keywords: inflammation; renal inflammation; mediated renal; nlrc5 transcription ... See more keywords
Th17 cells in renal inflammation and autoimmunity.
Sign Up to like & getrecommendations! Published in 2019 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2018.08.006
Abstract: Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-defining transcription factor RORγt. Th17 cells have a pivotal, physiological role in host defense against pathogens. These pro-inflammatory T-cells are also… read more here.
Keywords: cells renal; th17 cells; renal inflammation; autoimmunity ... See more keywords
LPS-induced renal inflammation is prevented by (−)‐epicatechin in rats
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2016.12.023
Abstract: This work investigated the capacity of (−)-epicatechin to prevent the renal damage induced by LPS administration in rats. Male Sprague Dawley rats were fed for 4 days a diet without or with supplementation with (−)-epicatechin… read more here.
Keywords: epicatechin rats; lps induced; inflammation prevented; renal inflammation ... See more keywords
Naringenin Ameliorates Hyperuricemia by Regulating Renal Uric Acid Excretion via the PI3K/AKT Signaling Pathway and Renal Inflammation through the NF-κB Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01513
Abstract: Hyperuricemia characterized by high serum levels of uric acid (UA, >6.8 mg/dL) is regarded as a common chronic metabolic disease. When used as a food supplement, naringenin might have various pharmacological activities, including antioxidant, free-radical-scavenging,… read more here.
Keywords: effects naringenin; signaling pathway; renal inflammation; excretion ... See more keywords
FP197SUPPRESSOR OF CYTOKINE SIGNALING-1/STAT1 REGULATES RENAL INFLAMMATION IN MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS MODELS
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfy104.fp197
Abstract: RESULTS: In this study, incidence of NDRD was 38%, DMN 42% and combined was 20%. CKD, NS and AKI were the most frequent clinical presentation. AIN, PIGN and CTID are commonest NDRD. These results suggest… read more here.
Keywords: fp197suppressor cytokine; stat1 regulates; cytokine signaling; renal inflammation ... See more keywords
Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury
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DOI: 10.1126/sciadv.abm0142
Abstract: The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood. Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on proximal tubular cells and peritubular capillaries of the kidney. Renal ischemia reperfusion… read more here.
Keywords: reperfusion injury; kidney; renal inflammation; recruitment ... See more keywords
miR-181a Improved Renal Inflammation by Targeting TNF-α in a Diabetic Nephropathy Animal Model
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DOI: 10.1159/000525050
Abstract: Introduction: Recent studies have elucidated that miR-181a plays a vital role in various inflammation-associated diseases; however, its role in the pathogenesis of diabetic nephropathy (DN) has not been elucidated clearly. Hence, we investigated the involvement… read more here.
Keywords: inflammation; mir 181a; renal inflammation; targeting tnf ... See more keywords
The C5a/C5aR2 axis promotes renal inflammation and tissue damage.
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DOI: 10.1172/jci.insight.134081
Abstract: C5a is a potent inflammatory mediator, which binds C5aR1 and C5aR2. Although pathogenic roles of C5a/C5aR1 axis in inflammatory disorders are well-documented, the roles for C5a/C5aR2 axis in inflammatory disorders and underlying mechanisms remain unclear.… read more here.
Keywords: c5ar2 axis; c5a; renal inflammation; c5a c5ar2 ... See more keywords
TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.136965
Abstract: TLR7 has been linked to the pathogenesis of glomerulonephritis, but its precise roles are not clear. In this study, we evaluated the roles of TLR7 in IgA nephropathy (IgAN). TLR7 proteins were abundant in CD19+… read more here.
Keywords: tlr7; iga nephropathy; inflammation iga1; renal inflammation ... See more keywords
IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016080840
Abstract: IL-36 cytokines are proinflammatory and have an important role in innate and adaptive immunity, but the role of IL-36 signaling in renal tubulointerstitial lesions (TILs), a major prognostic feature of renal inflammation and fibrosis, remains… read more here.
Keywords: inflammation fibrosis; renal inflammation; mice; activation ... See more keywords