B lymphocytes in renal interstitial fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0382-x
Abstract: Fibrosis is defined as an excessive deposition of extracellular matrix (ECM), which leads to the destruction of organ structure and impairment of organ function. Fibrosis occurs not only in kidney but also in lung, liver,… read more here.
Keywords: interstitial fibrosis; lymphocytes renal; fibrosis; renal interstitial ... See more keywords
Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-β/Smad signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114079
Abstract: Renal interstitial fibrosis (RIF) is a major pathological feature of chronic kidney disease at middle and end stages. Chrysophanol (CP), 1,8-dihydroxy-3-methyl-9,10-anthraquinone, is an anthraquinone isolated from Rheum palmatum L.with a variety of pharmacological activities including… read more here.
Keywords: interstitial fibrosis; fibrosis; tgf smad; tgf ... See more keywords
Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.06.028
Abstract: Iron is an essential mineral for oxygen delivery and for a variety of enzymatic activities, but excessive iron results in oxidative cytotoxicity. Because iron is primarily used in red blood cells, defective erythropoiesis caused by… read more here.
Keywords: production; interstitial fibroblasts; renal interstitial; iron ... See more keywords
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112856
Abstract: Renal interstitial fibrosis (RIF) is the common irreversible pathway by which chronic kidney disease (CKD) progresses to the end stage. The transforming growth factor-β (TGF-β)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is… read more here.
Keywords: interstitial fibrosis; saa1; endoplasmic reticulum; reticulum stress ... See more keywords
Integrating Polydopamine Nanosphere/Aptamers Nanoplatform with DNase-I-assisted Recycling Amplification Strategy for Simultaneous Detection of MMP-9 and MMP-2 During Renal Interstitial Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "ACS sensors"
DOI: 10.1021/acssensors.0c00058
Abstract: Matrix metalloproteinase-9 (MMP-9) and matrix metalloproteinase-2 (MMP-2) play important roles in the progression of renal interstitial fibrosis (RIF). There is an increasing demand to construct a novel method for simultaneous detection of MMP-9 and MMP-2… read more here.
Keywords: mmp; simultaneous detection; renal interstitial; strategy ... See more keywords
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2097700
Abstract: Abstract Context Baicalin, a flavonoid extracted from radix scutellariae, possesses various pharmacological effects, including protective effects on renal interstitial fibrosis (RIF), but its possible role and mechanisms have not been fully elucidated. Objective This study… read more here.
Keywords: baicalin; tgf smad; interstitial fibrosis; mice ... See more keywords
Myo-Inositol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy by Inhibiting PI3K/AKT Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal food"
DOI: 10.1089/jmf.2022.k.0152
Abstract: Emerging evidence suggests that myo-inositol (MI) has a critical role in reducing renal inflammatory processes and improving podocyte function and preventing diabetes-related renal damage. We aimed to explore the function and underlying workings of MI… read more here.
Keywords: pi3k akt; myo inositol; interstitial fibrosis; renal interstitial ... See more keywords
LncRNA HOTAIR promotes renal interstitial fibrosis by regulating Notch1 pathway via the modulation of miR‐124
Sign Up to like & getrecommendations! Published in 2019 at "Nephrology"
DOI: 10.1111/nep.13394
Abstract: To understand the mechanism of long non‐coding RNA (LncRNA) HOTAIR on renal interstitial fibrosis (RIF) by regulating Notch1 pathway via the modulation of miR‐124. read more here.
Keywords: interstitial fibrosis; notch1 pathway; pathway via; renal interstitial ... See more keywords
Knockdown of miR-214 Alleviates Renal Interstitial Fibrosis by Targeting the Regulation of the PTEN/PI3K/AKT Signalling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7553928
Abstract: The microRNA-214 (miR-214) precursor is formed by the DNM3 gene on human chromosome 1q24.3, which is encoded and transcribed in the nucleus and processed into mature miR-214 in the cytoplasm. Association of miR-214 with the… read more here.
Keywords: akt signalling; pi3k akt; interstitial fibrosis; mir 214 ... See more keywords
Renal Interstitial Inflammation Predicts Nephropathy Progression in IgA Nephropathy: A Two-Center Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Nephrology"
DOI: 10.1159/000524585
Abstract: Introduction: Renal interstitial inflammation often presents in immunoglobulin A nephropathy (IgAN), but its predictive role in kidney disease progression remains controversial. Methods: This retrospective two-center cohort study included 1,420 adult IgAN patients between January 2003… read more here.
Keywords: inflammation; kidney; progression; none mild ... See more keywords
Microvesicles containing microRNA-21 secreted by proximal tubular epithelial cells are involved in renal interstitial fibrosis by activating AKT pathway.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201802_14297
Abstract: OBJECTIVE To investigate the role of microvesicles containing microRNA-21 in renal interstitial fibrosis and its possible mechanism. MATERIALS AND METHODS The renal interstitial fibrosis model was established by unilateral ureteral obstruction, and proximal tubule epithelial… read more here.
Keywords: interstitial fibrosis; fibrosis; containing microrna; microrna secreted ... See more keywords