Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13029-4
Abstract: Proteins involved in iron homeostasis have been identified as biomarkers for lupus nephritis, a serious complication of systemic lupus erythematosus (SLE). We tested the hypothesis that renal iron accumulation occurs and contributes to renal injury… read more here.
Keywords: accumulation; renal iron; lupus nephritis; mice ... See more keywords
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0038
Abstract: Progressive iron accumulation and renal impairment are prominent in both patients and mouse models of sickle cell disease (SCD). Endothelin A receptor (ETA) antagonism prevents this iron accumulation phenotype and reduces renal iron deposition in… read more here.
Keywords: iron overload; renal iron; iron; iron accumulation ... See more keywords
Evidence of Renal Iron Accumulation in a Male Mouse Model of Lupus
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00516
Abstract: Lupus nephritis represents a common and serious complication of the autoimmune disease Systemic Lupus Erythematosus (SLE). Clinical studies suggest that several proteins related to iron metabolism, including transferrin, serve as urinary biomarkers of lupus nephritis.… read more here.
Keywords: iron; mouse model; renal iron; iron accumulation ... See more keywords