Hepatocyte nuclear factor 1 in renal lipid metabolism: molecular mechanisms and therapeutic potentials
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-10097-5
Abstract: Kidney disease is increasingly linked to dysregulated lipid metabolism, yet the molecular mechanisms driving renal lipotoxicity remain poorly understood. This review elucidates the pivotal role of the hepatic nuclear factor-1 family (HNF-1α and HNF-1β) in… read more here.
Keywords: lipid metabolism; molecular mechanisms; factor; metabolism ... See more keywords
Renal lipid accumulation induced by high-fat diet regulates glucose homeostasis via sodium-glucose cotransporter 2.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2021.109027
Abstract: AIMS Visceral lipid accumulation is involved in a variety of physiological aberrations. In the current study, we aimed to investigate whether lipid accumulation had an impact on glucose reabsorption in the kidney. METHODS We examined… read more here.
Keywords: accumulation; sodium glucose; lipid accumulation; expression ... See more keywords
Chlorogenic acid alleviates renal fibrosis by reducing lipid accumulation in diabetic kidney disease through suppressing the Notch1 and Stat3 signaling pathway
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DOI: 10.1080/0886022x.2024.2371988
Abstract: Abstract Aims Abnormal renal lipid metabolism causes renal lipid deposition, which leads to the development of renal fibrosis in diabetic kidney disease (DKD). The aim of this study was to investigate the effect and mechanism… read more here.
Keywords: fibrosis; renal fibrosis; stat3 signaling; notch1 stat3 ... See more keywords
In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3T: Feasibility and Reliability Study
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DOI: 10.3390/metabo12050386
Abstract: A reliable and practical renal-lipid quantification and imaging method is needed. Here, the feasibility of an accelerated MRSI method to map renal fat fractions (FF) at 3T and its repeatability were investigated. A 2D density-weighted… read more here.
Keywords: renal lipid; lipid quantification; feasibility; mrsi ... See more keywords
New insights into renal lipid dysmetabolism in diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2021 at "World Journal of Diabetes"
DOI: 10.4239/wjd.v12.i5.524
Abstract: Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs, including the kidney. Research suggests that impaired… read more here.
Keywords: lipid dysmetabolism; diabetic kidney; dysmetabolism; renal lipid ... See more keywords