GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-019-00711-6
Abstract: Dyslipidemia is a common risk factor of chronic kidney disease (CKD). Current notion suggests that insufficient intracellular fatty acid oxidation (FAO) and subsequently enhanced fatty acid esterification within renal resident cells, a process termed as… read more here.
Keywords: acetylation; lipotoxicity; fatty acid; renal lipotoxicity ... See more keywords
Renal lipotoxicity: Insights from experimental models
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13556
Abstract: In recent decades, there has been a progressive increase in the prevalence of obesity and chronic kidney disease. Renal lipotoxicity has been associated with obesity. Although lipids play fundamental physiological roles, the accumulation of lipids… read more here.
Keywords: experimental models; lipotoxicity; lipotoxicity insights; insights experimental ... See more keywords
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.140483
Abstract: Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis… read more here.
Keywords: disease; diabetic kidney; renal lipotoxicity; stk25 ... See more keywords