Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2018.09.005
Abstract: Renal medullary carcinoma (RMC) is one of the most aggressive renal cell carcinomas. It predominantly afflicts young adults and adolescents with sickle cell trait and other sickle hemoglobinopathies, and is refractory to targeted and antiangiogenic… read more here.
Keywords: management clinical; carcinoma; diagnosis management; medullary carcinoma ... See more keywords
Next Generation Sequencing of Renal Medullary Carcinoma Diagnosed Concurrently with Sickle Cell Trait: A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.164
Abstract: We present a 33-year-old African American male with 4 months of intermittent right flank pain and gross hematuria with hypermetabolic retroperitoneal lymphadenopathy, persistent right-sided hydronephrosis, perinephric fat stranding and a 5.5-cm hypermetabolic right lower pole… read more here.
Keywords: cell trait; renal medullary; sickle cell; medullary carcinoma ... See more keywords
Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.1101/2022.04.28.489873
Abstract: Renal medullary carcinoma (RMC) is a highly aggressive disease associated with sickle hemoglobinopathies and universal loss of the tumor suppressor gene SMARCB1. RMC has a relatively low rate of incidence compared with other renal cell… read more here.
Keywords: medullary carcinoma; renal medullary; tumor microenvironment; tumor ... See more keywords
Predictive role of PD-L1 expression in the response of renal Medullary carcinoma to PD-1 inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1186/s40425-017-0267-9
Abstract: BackgroundRenal medullary carcinoma is one of the rarest malignancies arising from the kidney. Despite various aggressive therapeutic regimens, mortality remains significantly high (95%) with a median overall survival of 5 months. Furthermore, the scarcity of this… read more here.
Keywords: response; predictive role; medullary carcinoma; renal medullary ... See more keywords
SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.21203/rs.3.rs-1178801/v1
Abstract: Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin and oncogenic mechanism remain poorly understood. Using single-cell sequencing of human… read more here.
Keywords: medullary carcinoma; ferroptosis resistance; renal medullary; ferroptosis ... See more keywords
Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and Fibronectin in Collecting Duct Cells
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12030729
Abstract: Chronic diabetes mellitus (DM) can lead to kidney damage associated with increased reactive oxygen species (ROS), proteinuria, and tubular damage. Altered protein expression levels of transforming growth factor-beta 1 (TGF-β1), fibronectin, and renal NADPH oxidase… read more here.
Keywords: fibronectin; tgf fibronectin; renal medullary; expression ... See more keywords
Renal Medullary Carcinomas Harbor a Distinct Methylation Phenotype and Display Aberrant Methylation of Genes Related to Early Nephrogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205044
Abstract: Simple Summary Renal medullary carcinomas (RMC) are aggressive tumors of the kidneys, characterized by a loss of SMARCB1. As the tumors, arising predominantly in young males with sickle cell trait, are very rare and no… read more here.
Keywords: methylation; renal medullary; nephrogenesis; medullary carcinomas ... See more keywords
Recent Advances in Renal Medullary Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137097
Abstract: Renal medullary carcinoma (RMC) is a rare renal malignancy that has been associated with sickle hemoglobinopathies. RMC is aggressive, difficult to treat, and occurs primarily in adolescents and young adults of African ancestry. This cancer… read more here.
Keywords: medullary carcinoma; advances renal; renal medullary; biology ... See more keywords
Primary Hyperaldosteronism and Renal Medullary Nephrocalcinosis: A Controversial Association
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DOI: 10.5001/omj.2021.32
Abstract: Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5–10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest… read more here.
Keywords: nephrocalcinosis; hyperaldosteronism renal; primary hyperaldosteronism; renal medullary ... See more keywords
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.44161
Abstract: Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful patient-derived RMC models and using whole-genome sequencing, we identified loss-of-function intronic… read more here.
Keywords: smarcb1 loss; loss; carcinomas depend; renal medullary ... See more keywords