Sodium-glucose cotransporter 2 inhibitors at the intersection of cardiovascular, renal and metabolic care: an integrated and multidisciplinary approach to patient-centered care.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Cardiology"
DOI: 10.1097/hco.0000000000000774
Abstract: PURPOSE OF REVIEW The management of individuals who live with type 2 diabetes requires an integrated and multifaceted approach. RECENT FINDINGS Sodium-glucose cotransporter 2 inhibitors effectively prevent and treat cardiorenal complications in the presence of… read more here.
Keywords: care; cotransporter inhibitors; renal metabolic; sodium glucose ... See more keywords
SGLT2 inhibition potentiates the cardiovascular, renal, and metabolic effects of sGC stimulation in hypertensive rats with prolonged exposure to high-fat diet
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Heart and Circulatory Physiology"
DOI: 10.1152/ajpheart.00386.2021
Abstract: Prolonged high-fat diet (HFD) accelerates the cardiovascular, renal, and metabolic dysfunction in hypertensive rats with altered renal development (ARDev). Soluble guanylate cyclase (sGC) stimulation or sodium-glucose cotransporter 2 (SGLT2) inhibition may improve cardiovascular, renal, and… read more here.
Keywords: cardiovascular renal; renal metabolic; hypertensive rats; physiology ... See more keywords
Relationships between lifestyle patterns and cardio-renal-metabolic parameters in patients with type 2 diabetes mellitus: A cross-sectional study
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DOI: 10.1371/journal.pone.0173540
Abstract: Introduction While individuals tend to show accumulation of certain lifestyle patterns, the effect of such patterns in real daily life on cardio-renal—metabolic parameters remains largely unknown. This study aimed to assess clustering of lifestyle patterns… read more here.
Keywords: cardio renal; lifestyle patterns; metabolic parameters; patterns cardio ... See more keywords
Computational integration and meta-analysis of abandoned cardio-(vascular/renal/metabolic) therapeutics discontinued during clinical trials from 2011 to 2022
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1033832
Abstract: Cardiovascular/renal/metabolic (CVRM) diseases collectively comprise the leading cause of death worldwide and disproportionally affect older demographics and historically underrepresented minority populations. Despite these critical unmet needs, pharmaceutical research and development (R&D) efforts have historically struggled… read more here.
Keywords: information; renal metabolic; 2011 2022; therapeutics discontinued ... See more keywords
Diagnosing Arterial Stiffness in Pregnancy and Its Implications in the Cardio-Renal-Metabolic Chain
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DOI: 10.3390/diagnostics12092221
Abstract: Cardio-renal and metabolic modifications during gestation are crucial determinants of foetal and maternal health in the short and long term. The cardio-renal metabolic syndrome is a vicious circle that starts in the presence of risk… read more here.
Keywords: arterial stiffness; renal metabolic; cardio renal; pregnancy ... See more keywords