#1805 Renal progenitor cells isolated from urine of IgA nephropathy patients formed renal spheroids that can recapitulate the typical IgA1 deposition
Sign Up to like & getrecommendations! Published in 2024 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfae069.278
Abstract: Recent developments in stem cell biology have made it possible to create spheroids and kidney organoids from human and mouse pluripotent stem cells and renal stem cells. Spheroids are a suitable in vitro model for… read more here.
Keywords: renal progenitor; iga1 deposition; culture; arpc derived ... See more keywords
Development and intra-renal delivery of renal progenitor organoids for effective integration in vivo
Sign Up to like & getrecommendations! Published in 2024 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szae078
Abstract: Abstract Renal progenitor organoids have been proposed as a source of tissue for kidney regeneration; however, their clinical translatability has not been demonstrated due to an inability to mass-produce comprehensive renal progenitor organoids and the… read more here.
Keywords: renal progenitor; integration; delivery; progenitor ... See more keywords
Human Urine-Derived SIX2-Positive Renal Progenitor Cells Partially Improve Kidney Fibrosis by Paracrine Signaling.
Sign Up to like & getrecommendations! Published in 2025 at "Stem cells and development"
DOI: 10.1177/15473287251388416
Abstract: Cells with renal progenitor cells characteristics are shed in urine. This study aimed to investigate whether these SIX2-positive urine-derived renal progenitor cells (UdRPC) have therapeutic potential in treating or managing acute to chronic kidney injuries,… read more here.
Keywords: renal progenitor; fibrosis; progenitor cells; kidney ... See more keywords
Kidney Regeneration in Later-Stage Mouse Embryos via Transplanted Renal Progenitor Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019020148
Abstract: BACKGROUND The limited availability of donor kidneys for transplantation has spurred interest in investigating alternative strategies, such as regenerating organs from stem cells transplanted into animal embryos. However, there is no known method for transplanting… read more here.
Keywords: progenitor; kidney regeneration; renal progenitor; progenitor cells ... See more keywords
gldc Is Essential for Renal Progenitor Patterning during Kidney Development
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123220
Abstract: The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine levels and contributing one-carbon units to folate metabolism. Congenital mutations in GCS components, such as glycine… read more here.
Keywords: kidney; development; glycine; renal progenitor ... See more keywords