Protective effect of retinoic acid receptor α on hypoxia‐induced epithelial to mesenchymal transition of renal tubular epithelial cells associated with TGF‐β/MMP‐9 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10982
Abstract: Retinoic acid receptor α (RARα), a member of family of the nuclear retinoic acid receptors (RARs), plays an essential role in various chronic kidney diseases (CKD). Renal tubular epithelial to mesenchymal transition (EMT) is a… read more here.
Keywords: tgf mmp; retinoic acid; renal tubular; tubular epithelial ... See more keywords
IL‐1β functionally attenuates ABCG2 and PDZK1 expression in HK‐2 cells partially through NF‐ĸB activation
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DOI: 10.1002/cbin.11100
Abstract: Long‐standing untreated hyperuricemia could lead to gout. Several recent studies have demonstrated a significant decrease of serum urate during acute gout attack, which is an aseptic inflammation process focusing on IL‐1β. However, how IL‐1β, by… read more here.
Keywords: epithelial cells; attenuates abcg2; renal tubular; expression ... See more keywords
Renal Tubular Handling of Glucose and Fructose in Health and Disease.
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DOI: 10.1002/cphy.c210030
Abstract: The proximal tubule of the kidney is programmed to reabsorb all filtered glucose and fructose. Glucose is taken up by apical sodium-glucose cotransporters SGLT2 and SGLT1 whereas SGLT5 and potentially SGLT4 and GLUT5 have been… read more here.
Keywords: tubular handling; renal tubular; glucose fructose; proximal tubule ... See more keywords
Renal tubular dysfunction and cancer mortality in the Japanese general population living in cadmium‐non‐contaminated areas
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DOI: 10.1002/jat.4304
Abstract: The relationship between cadmium exposure, exposure‐related renal tubular dysfunction, and mortality have been reported, mainly in the residents of Cd‐contaminated areas in Japan. The aim of this study was to establish the cause–effect relationship between… read more here.
Keywords: contaminated areas; non contaminated; cadmium; renal tubular ... See more keywords
Ox-LDL aggravates contrast-induced injury of renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23379
Abstract: Hypercholesterolemia can aggravate contrast-induced acute kidney injury, and the exacerbation of renal tubular epithelial cell (RTEC) injury is a major cause. However, the exact mechanisms remain obscure. Mitophagy, a type of autophagy, selectively eliminates damaged… read more here.
Keywords: induced injury; contrast induced; renal tubular; mitophagy ... See more keywords
Protein Network Analysis and Functional Studies of Calcium Oxalate Crystal‐Induced Cytotoxicity in Renal Tubular Epithelial Cells
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DOI: 10.1002/pmic.201800008
Abstract: Our previous expression study has reported a set of proteins with altered levels in renal tubular cells after exposure to calcium oxalate monohydrate (COM) crystals, which are the main composition of kidney stones. However, their… read more here.
Keywords: protein network; analysis; renal tubular; calcium oxalate ... See more keywords
Cadmium exposure induces autophagy via PLC‐IP3‐IP3R signaling pathway in duck renal tubular epithelial cells
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DOI: 10.1002/tox.23626
Abstract: Cadmium (Cd) is detrimental to animals, but nephrotoxic effects of Cd on duck have not been fully elucidated. To evaluate the impacts of Cd on Ca homeostasis and autophagy via PLC‐IP3‐IP3R pathway, primary duck renal… read more here.
Keywords: ip3 ip3r; renal tubular; plc ip3; plc ... See more keywords
Inhibition of the BNIP3/NIX‐dependent mitophagy aggravates copper‐induced mitochondrial dysfunction in duck renal tubular epithelial cells
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DOI: 10.1002/tox.23704
Abstract: The accumulation of copper (Cu) in the organisms could lead to kidney damage by causing mitochondrial dysfunction. Given that mitochondria are one of the targets of Cu poisoning, this study aimed to investigate the role… read more here.
Keywords: induced mitochondrial; bnip3 nix; renal tubular; mitochondrial dysfunction ... See more keywords
Epigenetic activation of CTGF transcription by high glucose in renal tubular epithelial cells is mediated by myocardin-related transcription factor A
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03124-5
Abstract: Diabetic nephropathy (DN) is one of the most devastating complications of diabetes. Connective tissue growth factor (CTGF) levels are up-regulated in patients with DN and in renal tubular epithelial cells (RTECs) exposed to high glucose… read more here.
Keywords: transcription; factor; renal tubular; tubular epithelial ... See more keywords
Bi-allelic mutations in renin-angiotensin system genes, associated with renal tubular dysgenesis, can also present as a progressive chronic kidney disease
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DOI: 10.1007/s00467-020-04524-4
Abstract: Background Bi-allelic loss of function variations in genes encoding proteins of the renin-angiotensin system ( AGT , ACE , REN , AGTR1 ) are associated with autosomal recessive renal tubular dysgenesis, a severe disease characterized… read more here.
Keywords: tubular dysgenesis; disease; renin angiotensin; renal tubular ... See more keywords
Induction of inactive TGF-β1 monomer formation by hydrogen sulfide contributes to its suppressive effects on Ang II- and TGF-β1-induced EMT in renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.032
Abstract: Hydrogen sulfide (H2S), an endogenous gas mediator with multifaced biological functions, has been shown to be effective in the prevention and treatment of renal sclerosis in several models of chronic renal diseases. The mechanisms involved… read more here.
Keywords: tgf; renal tubular; tgf induced; ang tgf ... See more keywords