Hypoxia and Renal Tubulointerstitial Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_23
Abstract: Hypoxia, one of the most common causes of kidney injury, is a key pathological condition in various kidney diseases. Renal fibrosis is the terminal pathway involved in the continuous progression of chronic kidney disease (CKD),… read more here.
Keywords: fibrosis; hypoxia renal; biology; tubulointerstitial fibrosis ... See more keywords
P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency
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DOI: 10.1038/s41598-017-06868-8
Abstract: To determine whether p16INK4a deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1−/−) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16INK4a double-knockout, and Bmi-1−/− and wild-type mice.… read more here.
Keywords: tubulointerstitial injury; bmi; senescence; p16ink4a deletion ... See more keywords
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
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DOI: 10.1042/cs20200171
Abstract: Hyperglycemia-induced renal epithelial to mesenchymal transition (EMT) is a key pathological factor in diabetic renal tubulointerstitial fibrosis (RIF). Our previous studies have shown that connexin 43 (Cx43) activation attenuated the development of diabetic renal fibrosis.… read more here.
Keywords: hif; renal tubulointerstitial; diabetic renal; tubulointerstitial fibrosis ... See more keywords
miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/4708516
Abstract: Redox imbalance plays an important role in the pathogenesis of CKD progression. Previously, we demonstrated that microRNA-382 (miR-382) contributed to TGF-β1-induced loss of epithelial polarity in human kidney epithelial cells, but its role in the… read more here.
Keywords: mir 382; mir; tubulointerstitial fibrosis; hspd1 ... See more keywords
circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.715567
Abstract: Renal tubulointerstitial fibrosis is a common pathological feature of progressive chronic kidney disease (CKD), and current treatment has limited efficacy. The circular RNA circHIPK3 is reported to participate in the pathogenesis of various human diseases.… read more here.
Keywords: renal fibrosis; circhipk3; mir 30a; tubulointerstitial fibrosis ... See more keywords