Development of a novel murine heart failure model overexpressing human renin and angiotensinogen
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12810
Abstract: Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the… read more here.
Keywords: renin; human renin; failure model; heart failure ... See more keywords
Combination Therapy of Renin Angiotensin System Inhibitors and β-Blockers in Patients with Heart Failure.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2018_179
Abstract: Renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system play crucial roles in heart failure with reduced ejection fraction (HFrEF). Clinical trials provide strong evidence of prognostic benefits for combination therapy with angiotensin-converting enzyme inhibitor (ACEI) and… read more here.
Keywords: system; renin; angiotensin; therapy ... See more keywords
A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Research in Cardiology"
DOI: 10.1007/s00392-020-01764-0
Abstract: Sham-controlled trials provided proof-of-principle for the blood pressure-lowering effect of catheter-based renal denervation (RDN). However, indicators for the immediate assessment of treatment success are lacking. This study sought to investigate the impact of RDN on… read more here.
Keywords: renal renin; hypotensive challenge; renal denervation; catheter based ... See more keywords
The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof
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DOI: 10.1007/s10557-021-07262-3
Abstract: Hydralazine, doxazosin, and verapamil are currently recommended by the Endocrine Society as acceptable bridging treatment in those in whom full cessation of antihypertensive medication is infeasible during screening for primary aldosteronism (PA). This is under… read more here.
Keywords: aldosterone; ratio; hydralazine doxazosin; renin ... See more keywords
Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry
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DOI: 10.1007/s12020-017-1348-8
Abstract: PurposeChronic inflammation is an age-independent and body mass index-independent contributor to the development of multi-morbidity. Alterations of the renin-angiotensin-aldosterone system are observed within the context of proinflammatory states. We assessed circulating aldosterone, renin, and inflammatory… read more here.
Keywords: plasma; primary aldosteronism; renin; study health ... See more keywords
Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02938-0
Abstract: During pregnancy, the renin–angiotensin–aldosterone system (RAAS) undergoes major changes to preserve normal blood pressure (BP) and placental blood flow and to ensure a good pregnancy outcome. Abnormal aldosterone–renin metabolism is a risk factor for arterial… read more here.
Keywords: cohort normotensive; pregnant women; renin; normotensive pregnant ... See more keywords
Micro- and macrovascular function in patients suffering from primary adrenal insufficiency: a cross-sectional case–control study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01309-2
Abstract: Background Despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, patients suffering from primary adrenal insufficiency (AI) have an increased mortality, mainly due to cardiovascular diseases. Only little knowledge exists on the contribution of MC… read more here.
Keywords: macrovascular function; primary adrenal; patients suffering; renin ... See more keywords
Effect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nephrology"
DOI: 10.1007/s40620-020-00944-5
Abstract: Acidosis-induced kidney injury is mediated by the intrarenal renin-angiotensin system, for which urinary renin is a potential marker. Therefore, we hypothesized that sodium bicarbonate supplementation reduces urinary renin excretion in patients with chronic kidney disease… read more here.
Keywords: renin; renin angiotensin; bicarbonate; angiotensin system ... See more keywords
The relation of RAAS activity and endothelin-1 levels to coronary atherosclerotic burden and microvascular dysfunction in chest pain patients.
Sign Up to like & getrecommendations! Published in 2022 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2022.03.017
Abstract: BACKGROUND AND AIMS In this study, we investigated whether increased renin angiotensin aldosterone system (RAAS) activation and endothelin-1 levels are related to coronary artery calcium (CAC) score, total plaque volume (TPV), high risk plaque, hyperemic… read more here.
Keywords: raas; renin; microvascular dysfunction; cad ... See more keywords
Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen
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DOI: 10.1016/j.heliyon.2019.e01409
Abstract: Background Plasma renin can predict future cardiovascular events as well as the prevalence of chronic renal disease in hypertensive subjects. Ovine angiotensinogen (oANG) is a better substrate for measuring renin concentration through activity assay. Recombinant… read more here.
Keywords: renin; measuring renin; recombinant oang; renin concentration ... See more keywords
Sympathetic and renin-angiotensin-aldosterone system activation in heart failure with preserved, mid-range and reduced ejection fraction.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.08.040
Abstract: BACKGROUND Evidence of sympathetic and renin-angiotensin-aldosterone system activation provided a rationale for neurohormonal antagonism in heart failure with reduced ejection fraction (HFrEF), while no data are available in patients with milder degree of systolic dysfunction.… read more here.
Keywords: hfpef hfmref; aldosterone; renin; hfmref ... See more keywords