The renin‐angiotensin system in COVID‐19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000112
Abstract: This renin‐angiotensin system (RAS) interpretation is focused on differences in tissue dependence on RAS and on the topological hierarchy that allows mediators to act only on downstream tissues. read more here.
Keywords: ace2 targeting; renin angiotensin; system covid; covid ace2 ... See more keywords
Impact of renin-angiotensin system inhibitors on long-term clinical outcomes of patients with rheumatic heart disease.
Sign Up to like & getrecommendations! Published in 2021 at "ESC heart failure"
DOI: 10.1002/ehf2.13623
Abstract: AIMS Rheumatic heart disease (RHD) remains a major global health problem. Renin-angiotensin-aldosterone system inhibitors (RAASi) are commonly administered in the treatment of cardiovascular disease, but its role in RHD patients is still limited. We performed… read more here.
Keywords: heart; new onset; treatment; disease ... See more keywords
Is hyperkalaemia in heart failure a risk factor or a risk marker? Implications for renin–angiotensin–aldosterone system inhibitor use
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1175
Abstract: For clinicians caring for patients with heart failure (HF), acute or chronic kidney disease (CKD), and/or diabetes mellitus, dyskalaemia and optimization of diuretics and renin– angiotensin–aldosterone system inhibitors (RAASi) are everyday concerns. Although we understand… read more here.
Keywords: renin angiotensin; risk; angiotensin aldosterone; heart failure ... See more keywords
The Dilemma of Renin Angiotensin System Blockers in Coronavirus Disease (Covid‐19): Insights on the Lung Fluid Handling and Gas Exchange in Heart Failure Patients
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DOI: 10.1002/ejhf.1910
Abstract: The coronavirus disease 2019 (COVID-19) pandemic is precipitating the global health crisis of our time, as stated by the World Health Organization (WHO). Since its surge in December 2019, in Wuhan, Hubei province, China, the… read more here.
Keywords: fluid; renin angiotensin; failure; gas exchange ... See more keywords
Effects of hyperkalaemia and non‐adherence to renin–angiotensin–aldosterone system inhibitor therapy in patients with heart failure in Italy: a propensity‐matched study
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2024
Abstract: The aims of this study were to evaluate if the risk of cardiovascular events and all‐cause mortality was higher in the presence of hyperkalaemia (HK) in patients with heart failure (HF) treated with renin–angiotensin–aldosterone system… read more here.
Keywords: heart; angiotensin aldosterone; heart failure; renin angiotensin ... See more keywords
Etiopathophysiological role of the renin–angiotensin–aldosterone system in age‐related muscular weakening: RAAS‐independent beneficial role of ACE2 in muscle weakness
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23030
Abstract: Aging is accompanied by major changes in body composition that can negatively affect functional status in older adults, including a progressive decrease in muscle mass, strength, and quality. The prevalence of sarcopenia has varied considerably,… read more here.
Keywords: system; role; muscle; muscle weakness ... See more keywords
The Interplay between the Immune System, the Renin Angiotensin Aldosterone System (RAAS) and RAAS Inhibitors May Modulate the Outcome of COVID‐19: A Systematic Review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1852
Abstract: Since the discovery of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), numerous research has been undertaken to delineate the various effects of the virus which manifests in many ways all over the body. The association… read more here.
Keywords: system; angiotensin aldosterone; covid; renin angiotensin ... See more keywords
Renin‐angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells
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DOI: 10.1002/stem.3339
Abstract: Angiotensin‐converting enzyme (ACE), a key element of the renin‐angiotensin system (RAS), has recently been identified as a new marker of both adult and embryonic human hematopoietic stem/progenitor cells (HSPCs). However, whether a full renin‐angiotensin pathway… read more here.
Keywords: renin angiotensin; stem progenitor; hematopoietic stem; angiotensin ... See more keywords
Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity
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DOI: 10.1007/s00392-019-01448-4
Abstract: BackgroundTrastuzumab-related cardiotoxicity (TRC) has been considered as reversible. However, recent studies have raised concern against reversibility of left ventricular (LV) systolic dysfunction in breast cancer patients treated with trastuzumab. In addition, the efficacy of medical… read more here.
Keywords: renin angiotensin; inhibitors blockers; angiotensin inhibitors; related cardiotoxicity ... See more keywords
Bi-allelic mutations in renin-angiotensin system genes, associated with renal tubular dysgenesis, can also present as a progressive chronic kidney disease
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DOI: 10.1007/s00467-020-04524-4
Abstract: Background Bi-allelic loss of function variations in genes encoding proteins of the renin-angiotensin system ( AGT , ACE , REN , AGTR1 ) are associated with autosomal recessive renal tubular dysgenesis, a severe disease characterized… read more here.
Keywords: tubular dysgenesis; disease; renin angiotensin; renal tubular ... See more keywords
Melatonin ameliorates intrarenal renin–angiotensin system in a 5/6 nephrectomy rat model
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DOI: 10.1007/s10157-017-1505-7
Abstract: BackgroundActivation of the intrarenal renin–angiotensin system (RAS) plays a critical role in the pathophysiology of chronic kidney disease (CKD) and hypertension. It has been reported that reactive oxygen species (ROS) are important components of intrarenal… read more here.
Keywords: intrarenal ras; intrarenal renin; renin angiotensin; model ... See more keywords