Systemic biopolymer-delivered vascular endothelial growth factor promotes therapeutic angiogenesis in experimental renovascular disease.
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DOI: 10.1016/j.kint.2017.09.029
Abstract: We recently developed a therapeutic biopolymer composed of an elastin-like polypeptide (ELP) fused to vascular endothelial growth factor (VEGF) and showed long-term renoprotective effects in experimental renovascular disease after a single intra-renal administration. Here, we… read more here.
Keywords: renovascular disease; vascular endothelial; endothelial growth; elp ... See more keywords
Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association
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DOI: 10.1161/hyp.0000000000000217
Abstract: Renovascular disease is a major causal factor for secondary hypertension and renal ischemic disease. However, several prospective, randomized trials for atherosclerotic disease failed to demonstrate that renal revascularization is more effective than medical therapy for… read more here.
Keywords: disease; renovascular disease; revascularization; revascularization renovascular ... See more keywords
Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their reparative Potency.
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DOI: 10.1161/hypertensionaha.120.16218
Abstract: Scattered tubular-like cells (STCs), dedifferentiated renal tubular epithelial cells, contribute to renal self-healing, but severe injury might blunt their effectiveness. We hypothesized that ischemic renovascular disease (RVD) induces senescence in STC and impairs their reparative… read more here.
Keywords: like cells; senescence; renovascular disease; disease ... See more keywords
With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease.
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DOI: 10.1161/hypertensionaha.121.17960
Abstract: The collateral circulation can adapt to bypass major arteries with limited flow and serves a crucial protective role in coronary, cerebral, and peripheral arterial disease. Emerging evidence indicates that the renal collateral circulation can similarly… read more here.
Keywords: collateral circulation; atherosclerotic renovascular; disease; renal collateral ... See more keywords
Endovascular Versus Medical Management of Atherosclerotic Renovascular Disease: Update and Emerging Concepts.
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DOI: 10.1161/hypertensionaha.122.17965
Abstract: Atherosclerotic renovascular disease is the most frequent cause of renovascular hypertension and its prevalence increases with age and in specific subset of patients, such as those with end-stage chronic kidney disease, heart failure, and coronary… read more here.
Keywords: atherosclerotic renovascular; disease; kidney; versus medical ... See more keywords
Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine
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DOI: 10.1177/0963689718780942
Abstract: Background: Extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) mediate their paracrine effect, but their efficacy to protect the microcirculation of the kidney is unknown. Using a novel swine model of unilateral renovascular disease… read more here.
Keywords: extracellular vesicles; mets rvd; renovascular disease; mesenchymal stem ... See more keywords