Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.006
Abstract: Reovirus induces tumor cell death efficiently and specifically, and thus is currently undergoing clinical testing as an anticancer agent. In the intracellular trafficking of reovirus, proteolytic disassembly of reovirus capsid-proteins and subsequent penetration of viral… read more here.
Keywords: cell killing; reovirus; tumor cells; tumor cell ... See more keywords
Development of an indirect ELISA assay for detecting antibodies against mammalian reovirus in pigs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2018.07.008
Abstract: Mammalian reovirus (MRV) infects many species. Over the past decades, MRV infections in pigs have been reported, and several highly pathogenic MRV strains have recently been isolated in the United States. In this study, an… read more here.
Keywords: mammalian reovirus; reovirus; assay detecting; elisa assay ... See more keywords
Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in Cairna moschata
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28499-3
Abstract: Duck reovirus (DRV) is an typical aquatic bird pathogen belonging to the Orthoreovirus genus of the Reoviridae family. Reovirus causes huge economic losses to the duck industry. Although DRV has been identified and isolated long… read more here.
Keywords: duck reovirus; reovirus; cairna moschata; ndrv infections ... See more keywords
Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-07259-2
Abstract: The recently identified novel duck reovirus (NDRV) is a waterfowl reovirus that can seriously harm or kill various waterfowl species. However, how NDRV interacts with host cells in Muscovy ducklings beyond the typical pathogenesis resulting… read more here.
Keywords: novel duck; duck reovirus; muscovy ducklings; reovirus ... See more keywords
Analysis of Emerging Variants of Turkey Reovirus using Machine Learning
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbae224
Abstract: Abstract Avian reoviruses continue to cause disease in turkeys with varied pathogenicity and tissue tropism. Turkey enteric reovirus has been identified as a causative agent of enteritis or inapparent infections in turkeys. The new emerging… read more here.
Keywords: emerging variants; reovirus; turkey reovirus; machine learning ... See more keywords
Intravesical Oncolytic Virotherapy and Immunotherapy for Non-Muscle Invasive Bladder Cancer Mouse Model.
Sign Up to like & getrecommendations! Published in 2023 at "BJU international"
DOI: 10.1111/bju.16012
Abstract: OBJECTIVES Non-muscle-invasive bladder cancer that is refractory to intravesical Bacillus Calmette-Guérin (BCG) may be treated by systemic anti-PD-1 (programmed cell death protein 1) immunotherapy. We previously demonstrated improved overall survival with 6 weekly instillations of… read more here.
Keywords: treatment; bladder cancer; model; reovirus ... See more keywords
An Unusual Aspartic Acid Cluster in the Reovirus Attachment Fiber σ1 Mediates Stability at Low pH and Preserves Trimeric Organization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00331-22
Abstract: Enteric viruses withstand the highly acidic environment of the stomach during transmission, and many of them use low pH as a trigger for conformational changes associated with entry. For many nonenveloped viruses, the structural basis… read more here.
Keywords: head; acid cluster; aspartic acid; reovirus ... See more keywords
The Reovirus σ3 Protein Inhibits NF-κB-Dependent Antiviral Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00515-22
Abstract: Host cells mount a response to curb virus replication in infected cells and prevent spread of virus to neighboring, as yet uninfected, cells. The NF-κB family of proteins is important for the cell to mediate… read more here.
Keywords: dependent antiviral; response; reovirus; virus ... See more keywords
Reovirus Efficiently Reassorts Genome Segments during Coinfection and Superinfection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00910-22
Abstract: Reassortment, or genome segment exchange between viruses, can generate novel virus genotypes and pandemic virus strains. For viruses to reassort their genome segments, they must replicate within the same physical space by coinfecting the same… read more here.
Keywords: reovirus; genome segments; infection; superinfection ... See more keywords
Strain-specific differences in reovirus infection of murine macrophages segregate with polymorphisms in viral outer-capsid protein σ3
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.01147-24
Abstract: ABSTRACT Mammalian orthoreovirus (reovirus) strains type 1 Lang (T1L) and type 3 Dearing-RV (T3D-RV) infect the intestine in mice but differ in the induction of inflammatory responses. T1L infection is associated with the blockade of… read more here.
Keywords: oral immunological; reovirus; outer capsid; immunological tolerance ... See more keywords
Reovirus σ3 Protein Limits Interferon Expression and Cell Death Induction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01485-20
Abstract: We use mammalian reovirus as a model to study how virus infection modulates innate immune signaling and cell death induction. Here, we sought to determine how viral factors regulate these processes. Our work highlights a… read more here.
Keywords: cell death; reovirus; induction; protein ... See more keywords