3149 – DNA REPAIR AND CELL CYCLE ARE SYNTHETIC LETHAL PATHWAYS IN SRSF2P95H MUTATED CELLS
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DOI: 10.1016/j.exphem.2020.09.156
Abstract: Current strategies to target cells with mutations in the RNA splicing machinery have focused on the disruption of normal splicing activities. However, splicing inhibitors are also toxic to wild-type cells as has been demonstrated in… read more here.
Keywords: dna repair; repair cell; cell; srsf2p95h ... See more keywords
Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118730
Abstract: Reserpine is a natural indole alkaloid isolated from Rauwolfia serpentina and has potent antioxidant, antimicrobial, and anti-mutagenic properties. Accordingly, this study aimed to investigate the effect of reserpine on DNA repair, cell proliferation, invasion and… read more here.
Keywords: proliferation invasion; dna repair; cell proliferation; repair cell ... See more keywords