Exploiting DNA repair defects in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12467
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer‐related deaths worldwide. Therapies that take advantage of defects in DNA repair pathways have been explored in the context of breast, ovarian, and other tumor types,… read more here.
Keywords: dna repair; colorectal cancer; repair defects; exploiting dna ... See more keywords
DNA repair defects in prostate cancer: impact for screening, prognostication and treatment
Sign Up to like & getrecommendations! Published in 2019 at "BJU International"
DOI: 10.1111/bju.14576
Abstract: Failure of effective DNA damage repair is a hallmark of cancer, but was previously underappreciated as a driver of aggressive prostate cancer. However, recent international sequencing efforts have revealed that both germline and somatic alterations… read more here.
Keywords: dna repair; repair defects; prostate cancer; cancer ... See more keywords
Assessment of inherited DNA repair defects in African-American and Caucasian men with prostate cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.185
Abstract: 185Background: Pathogenic inherited DNA repair defects are well described in Caucasian American (CA) men with prostate cancer (PCa) but comparative data with large subsets of African-American (AA) ... read more here.
Keywords: dna repair; inherited dna; repair defects; prostate cancer ... See more keywords
Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24797
Abstract: Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and patient outcome. Their functional impact and clinical relevance in head and neck squamous… read more here.
Keywords: fanconi anemia; dna; repair defects; variants associated ... See more keywords
The Repair of Defects in High-Manganese Steel Castings by Welding Technology
Sign Up to like & getrecommendations! Published in 2021 at "Defect and Diffusion Forum"
DOI: 10.4028/www.scientific.net/ddf.410.209
Abstract: Welding technologies are used to repair defects in cast parts of high - manganese austenitic steel (Hadfield steel). These include repair welding for newly manufactured castings, welding the formed defects in the old operating cast… read more here.
Keywords: steel; castings welding; metal; repair defects ... See more keywords