Toxicity and repair of DNA adducts produced by the natural product yatakemycin
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2439
Abstract: Yatakemycin (YTM) is an extraordinarily toxic DNA alkylating agent with potent antimicrobial and antitumor properties and the most recent addition to the CC-1065 and duocarmycin family of natural products. While bulky DNA lesions the size… read more here.
Keywords: toxicity repair; dna adducts; toxicity; repair dna ... See more keywords
A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1641388
Abstract: ABSTRACT Long noncoding RNAs (lncRNAs) have emerged as critical regulators for gene expression in multiple levels and thus are involved in various physiological and pathological processes. Sirtuin 1 (SIRT1) has been established to exert key… read more here.
Keywords: sirt1; positive feedback; sirt1 mir17hg; repair dna ... See more keywords
Timely termination of repair DNA synthesis by ATAD5 is important in oxidative DNA damage-induced single-strand break repair
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab999
Abstract: Abstract Reactive oxygen species (ROS) generate oxidized bases and single-strand breaks (SSBs), which are fixed by base excision repair (BER) and SSB repair (SSBR), respectively. Although excision and repair of damaged bases have been extensively… read more here.
Keywords: dna synthesis; repair dna; h2o2; single strand ... See more keywords
Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1056
Abstract: Abstract Alternative end-joining (alt-EJ) repair of DNA double-strand breaks is associated with deletions, chromosome translocations, and genome instability. Alt-EJ frequently uses annealing of microhomologous sequences to tether broken ends. When accessible pre-existing microhomologies do not… read more here.
Keywords: dna; repair dna; strand breaks; double strand ... See more keywords
COMMD1, from the Repair of DNA Double Strand Breaks, to a Novel Anti-Cancer Therapeutic Target
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040830
Abstract: Simple Summary Lung cancer is the most commonly diagnosed cancer worldwide and additionally the most common cause of death from cancer, with non-small cell lung cancers (NSCLC) being the most commonly diagnosed form of the… read more here.
Keywords: dna double; repair dna; commd1; double strand ... See more keywords
Special Issue “DNA Replication/Repair, and the DNA Damage Response in Human Disease”
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14040893
Abstract: Mutations of numerous genes involved in DNA replication, DNA repair, and DNA damage response (DDR) pathways lead to a variety of human diseases, including aging and cancer [...]. read more here.
Keywords: dna damage; repair dna; damage response; dna replication ... See more keywords
ATR inhibitor AZD6738 increases the sensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting repair of DNA damage
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Reports"
DOI: 10.3892/or.2022.8289
Abstract: The repair of DNA damage caused by chemotherapy in cancer cells occurs mainly at two cell cycle checkpoints (G1 and G2) and is a factor contributing to chemoresistance. Most colorectal cancers harbor mutations in p53,… read more here.
Keywords: cancer; dna damage; repair dna; colorectal cancer ... See more keywords