Assessment of DNA repair efficiency in the inbred BTBR T + tf/J autism spectrum disorder mouse model exposed to gamma rays and treated with JNJ7777120
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.04.003
Abstract: Information regarding DNA repair in autism is limited to a few studies, which have reported inconsistent results. Therefore, we designed a study to determine whether DNA repair efficiency is altered in autism and to investigate… read more here.
Keywords: dna repair; dna; btbr mice; mice ... See more keywords
The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf048
Abstract: Abstract Lung cancer sequencing efforts have uncovered mutational signatures that are attributed to exposure to the cigarette smoke carcinogen benzo[a]pyrene. Benzo[a]pyrene metabolizes in cells to benzo[a]pyrene diol epoxide (BPDE) and reacts with guanine nucleotides to… read more here.
Keywords: mutagenesis; repair efficiency; damage; repair ... See more keywords
Reduction of DNA damage repair efficiency and accumulation of residual damage following chronic UVB-irradiation of HaCaT cells
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283572
Abstract: Absorption of ultraviolet radiation (UVR) by DNA leads to the predominant formation of cyclobutane pyrimidine dimers (CPD). Since those CPD are responsible for the driver mutations found in skin cancers, their efficient repair is critical.… read more here.
Keywords: repair efficiency; damage; accumulation residual; repair ... See more keywords
ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency
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DOI: 10.7150/ijbs.41246
Abstract: Repair of damaged DNA induced by radiation plays an important role in the development of radioresistance, which greatly restricts patients' benefit from radiotherapy. However, the relation between radioresistance development and DNA double-strand break repair pathways… read more here.
Keywords: dna repair; breast cancer; cancer cells; cancer ... See more keywords