Inborn errors of metabolite repair
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12187
Abstract: It is traditionally assumed that enzymes of intermediary metabolism are extremely specific and that this is sufficient to prevent the production of useless and/or toxic side‐products. Recent work indicates that this statement is not entirely… read more here.
Keywords: metabolite repair; classical metabolites; non classical; inborn errors ... See more keywords
Structural Insight into the Discrimination between 8-Oxoguanine Glycosidic Conformers by DNA Repair Enzymes: A Molecular Dynamics Study of Human Oxoguanine Glycosylase 1 and Formamidopyrimidine-DNA Glycosylase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b01292
Abstract: hOgg1 and FPG are the primary DNA repair enzymes responsible for removing the major guanine (G) oxidative product, namely, 7,8-dihydro-8-oxoguanine (OG), in humans and bacteria, respectively. While natural G adopts the anti conformation and forms… read more here.
Keywords: dna repair; molecular dynamics; oxoguanine; repair enzymes ... See more keywords
DNA repair enzymes of the Antarctic Dry Valley metagenome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1156817
Abstract: Microbiota inhabiting the Dry Valleys of Antarctica are subjected to multiple stressors that can damage deoxyribonucleic acid (DNA) such as desiccation, high ultraviolet light (UV) and multiple freeze-thaw cycles. To identify novel or highly-divergent DNA-processing… read more here.
Keywords: dna repair; dna; antarctic dry; enzymes antarctic ... See more keywords
Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging
Sign Up to like & getrecommendations! Published in 2023 at "Catalysts"
DOI: 10.3390/catal13040745
Abstract: Ultraviolet radiation (UVR) has been scientifically proven to cause skin disorders such as sunburn, skin cancer and the symptoms of chronic exposure. Natural sun screening compounds have recently gained tremendous attention from the cosmetic and… read more here.
Keywords: dna repair; sun screening; natural sun; screening compounds ... See more keywords
Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097954
Abstract: The DNA repair system plays a crucial role in maintaining the integrity of the genome [...]. read more here.
Keywords: dna repair; enzymes valuable; dna; inhibition dna ... See more keywords