Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response
Sign Up to like & getrecommendations! Published in 2022 at "Cell Research"
DOI: 10.1038/s41422-021-00597-4
Abstract: In response to DNA double-strand breaks (DSBs), DNA damage repair factors are recruited to DNA lesions and form nuclear foci. However, the underlying molecular mechanism remains largely elusive. Here, by analyzing the localization of DSB… read more here.
Keywords: pre; repair; repair factors; dsb repair ... See more keywords
Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation.
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DOI: 10.1080/09553002.2021.1948139
Abstract: PURPOSE To provide an updated summary of recent advances in our understanding of the non-canonical roles of apoptotic and DNA double-strand break repair factors in various biological processes, especially in the cellular response to radiotherapy.… read more here.
Keywords: repair factors; canonical roles; roles apoptotic; non canonical ... See more keywords
DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks
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DOI: 10.3389/fphys.2018.00516
Abstract: Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability. DNA damage checkpoint… read more here.
Keywords: dna damage; repair factors; checkpoint; dna ... See more keywords
The Role of Replication-Associated Repair Factors on R-Loops
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DOI: 10.3390/genes8070171
Abstract: The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication processes… read more here.
Keywords: repair factors; dna; replication associated; role ... See more keywords