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Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3747
Abstract: DNA repair processes are critical to maintaining genomic integrity. As a result, dysregulation of repair genes is likely to be linked with health implications, such as an increased prevalence of infertility and an accelerated rate…
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Keywords:
dna repair;
dna;
repair genes;
analysis ... See more keywords
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Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2915-4
Abstract: BackgroundLower-grade gliomas (LGGs, defined as WHO grades II and III) with 1p19q codeletion have increased chemosensitivity when compared to LGGs without 1p19q codeletion, but the mechanism is currently unknown.MethodsRNAseq data from 515 LGG patients in…
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Keywords:
repair genes;
expression dna;
dna repair;
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Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102779
Abstract: Summary Long-lived organisms are exposed to the risk of accumulating mutations due to DNA damage. Previous studies in animals have revealed the positive relationship between the copy number of DNA repair genes and longevity. However,…
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Keywords:
copy number;
longevity;
dna repair;
repair genes ... See more keywords
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Published in 2020 at "Journal of the American College of Surgeons"
DOI: 10.1016/j.jamcollsurg.2020.06.019
Abstract: BACKGROUD The frequency and significance of the germline variants in DNA damage repair genes still need to be elucidated in patients with sporadic pancreatic ductal adenocarcinoma (PDAC). Our purpose was to determine whether germline variants…
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Keywords:
damage repair;
dna damage;
repair genes;
germline variants ... See more keywords
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Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.03.012
Abstract: The association between Xeroderma Pigmentosum DNA repair genes (XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) polymorphisms and myelodysplastic syndrome (MDS) have not been reported. To assess the functional role between these polymorphisms and…
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Keywords:
pigmentosum dna;
dna repair;
dna;
xeroderma pigmentosum ... See more keywords
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Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.04.003
Abstract: There is substantial evidence of impaired DNA repair activities in Alzheimer's disease (AD) neurons and peripheral tissues, inducing some investigators to speculate that this could partially result from promoter hypermethylation of DNA repair genes, resulting…
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Keywords:
methylation;
dna repair;
dna;
alzheimer disease ... See more keywords
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Published in 2017 at "Clinical and Translational Gastroenterology"
DOI: 10.1038/ctg.2017.35
Abstract: Objectives:Approximately 35% of colorectal cancer (CRC) risk is attributable to heritable factors known hereditary syndromes, accounting for 6%. The remainder may be due to lower penetrance polymorphisms particularly of DNA repair genes. DNA repair pathways,…
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Keywords:
risk;
dna repair;
penetrance;
cancer ... See more keywords
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Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2018.4310
Abstract: To understand the molecular mechanism underlying the causal relationship between aberrant upregulation of transforming growth factor beta (TGF-β) and radio-resistance in glioma. The mouse glioma cell GL261 was irradiated, and relative expression of TGF-β/Smad signaling…
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Keywords:
glioma;
dna repair;
tgf;
repair genes ... See more keywords
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Published in 2020 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djaa132
Abstract: BACKGROUND There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline variants in DNA repair genes are associated…
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Keywords:
repair genes;
aggressive non;
dna repair;
non aggressive ... See more keywords
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Published in 2018 at "European Journal of Haematology"
DOI: 10.1111/ejh.12966
Abstract: We read with great interest the study of Valka et al. [1], recently published and we would like to reinforce the importance of DNA repair genes in the pathogenesis of myelodysplastic syndrome (MDS). The authors monitored…
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Keywords:
dna repair;
dna;
myelodysplastic syndrome;
expression ... See more keywords
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Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15325
Abstract: There have been a large number of epidemiologic studies regarding the association between genetic polymorphisms in DNA repair genes and onset of cervical cancer. However, results are inconsistent.
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Keywords:
cervical cancer;
dna repair;
polymorphisms dna;
genetic polymorphisms ... See more keywords