Coordination of transcription-coupled repair and repair-independent release of lesion-stalled RNA polymerase II
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DOI: 10.1038/s41467-024-51463-x
Abstract: Transcription-blocking lesions (TBLs) stall elongating RNA polymerase II (Pol II), which then initiates transcription-coupled repair (TCR) to remove TBLs and allow transcription recovery. In the absence of TCR, eviction of lesion-stalled Pol II is required… read more here.
Keywords: lesion stalled; pol; repair; transcription ... See more keywords
Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy
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DOI: 10.1038/srep45385
Abstract: Beclin 1 is a well-established core mammalian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show that Beclin 1 is a prenatal primary cytoplasmic… read more here.
Keywords: dna damage; beclin; repair independent; repair ... See more keywords