Germline DNA Repair Mutations and Response to Hormonal Therapy in Advanced Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "European urology"
DOI: 10.1016/j.eururo.2017.03.003
Abstract: It is increasingly understood that the prevalence of inherited DNA repair mutations in men with recurrent or advanced prostate cancer (PC)—especially those in genes regulating homologous recombination—is higher than previously recognized. In a recent landmark… read more here.
Keywords: dna repair; dna; germline dna; repair mutations ... See more keywords
Abstract IA10: DNA repair mutations in ovarian carcinoma and relationship to therapeutic response
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.dnarepair16-ia10
Abstract: Ovarian carcinomas with germline or somatic mutations in BRCA1 and BRCA2 are sensitive to platinum chemotherapy and to PARP inhibitors. The therapeutic role of damaging mutations in other homologous recombination genes is less certain. We… read more here.
Keywords: repair mutations; therapeutic response; mutations ovarian; dna repair ... See more keywords
Treatment outcomes in metastatic prostate cancer patients with DNA damage repair mutations.
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DOI: 10.1200/jco.2020.38.6_suppl.187
Abstract: 187Background: DNA damage repair mutations (DDM) are common in prostate cancer (PCa). Optimal treatment sequence and outcomes of androgen signaling inhibitors (ASIs) and chemotherapy in this popula... read more here.
Keywords: damage repair; dna damage; prostate cancer; repair mutations ... See more keywords