PARG and BRCA1–BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1153
Abstract: Abstract Meiotic chromosome segregation relies on programmed DNA double-strand break induction. These are in turn repaired by homologous recombination, generating physical attachments between the parental chromosomes called crossovers. A subset of breaks yields recombinant outcomes,… read more here.
Keywords: dna repair; function; pathway choice; parg ... See more keywords
CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice.
Sign Up to like & getrecommendations! Published in 2021 at "Aging cell"
DOI: 10.1111/acel.13484
Abstract: Werner syndrome (WS) is an accelerated aging disorder characterized by genomic instability, which is caused by WRN protein deficiency. WRN participates in DNA metabolism including DNA repair. In a previous report, we showed that WRN… read more here.
Keywords: wrn; protein; pathway choice; phosphorylation ... See more keywords
Abstract 1476: Enhancing radiation sensitivity in CHD5 dysregulated NSCLC by targeting NHEJ repair pathway
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1476
Abstract: Lung cancer, particularly non-small cell lung cancer (NSCLC), is a leading cause of cancer deaths, with 5-year survival rates decreasing from 65% for localized cases to 9% for distant metastases. Radiation therapy's effectiveness is often… read more here.
Keywords: cancer; repair pathway; radiation; chd5 ... See more keywords
Abstract B011: CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway by affecting the UFL1 ubiquitination
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.dnarepair24-b011
Abstract: DNA double-strand breaks (DSBs) contribute to genome instability, a key feature of cancer. DSBs are mainly repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). We investigated the role of an isoform of the multifunctional… read more here.
Keywords: repair pathway; cdk9; dna repair; anaphase promoting ... See more keywords
DNA repair pathway alterations and correlation with immunotherapy response.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14150
Abstract: e14150 Background: Over the past decade, a better understanding of cancer biology has led to a revolution in immunotherapy. Checkpoint inhibitors (ICI), bispecific antibodies and agonistic agents have shown benefit in cancer treatment. Unfortunately, not… read more here.
Keywords: dna repair; repair pathway; response; immunotherapy ... See more keywords
XPD c.934G>A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.7668
Abstract: This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous… read more here.
Keywords: nucleotide excision; patients treated; excision repair; chemoradiation ... See more keywords
HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201802
Abstract: MRN complex and the HR repair pathway play a crucial role in the maintenance of neural stem cell fate under irradiation stress. read more here.
Keywords: crucial role; cell fate; stem cell; neural stem ... See more keywords
Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1111191
Abstract: Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic variants in… read more here.
Keywords: dna repair; repair pathway; cancer cases; cancer ... See more keywords
DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108868
Abstract: DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in the design of new strategies for treatments, the prevention of platinum-based chemoresistance, and the prolongation of… read more here.
Keywords: dna repair; ovarian cancer; cancer patients; patients treated ... See more keywords