LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "repair pathways" as a keyword



Characterization of DNA double‐strand break repair pathways in diffuse large B cell lymphoma

Sign Up to like & get
recommendations! Published in 2019 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.22921

Abstract: Efficient DNA repair is indispensable for maintaining genomic integrity in humans. Cancer associated deletions and mutations are mainly due to misrepaired DNA double‐strand breaks (DSBs). Classical nonhomologous end joining (c‐NHEJ) and homologous recombination (HR) are… read more here.

Keywords: lymphoma; repair pathways; dna double; cell ... See more keywords

The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens

Sign Up to like & get
recommendations! Published in 2022 at "FEMS Microbiology Reviews"

DOI: 10.1093/femsre/fuac035

Abstract: Abstract DNA double-strand breaks require repair or risk corrupting the language of life. To ensure genome integrity and viability, multiple DNA double-strand break repair pathways function in eukaryotes. Two such repair pathways, canonical non-homologous end… read more here.

Keywords: dna repair; filamentous pathogens; repair; repair pathways ... See more keywords

PARP1 in the intersection of different DNA repair pathways, memory formation, and sleep pressure in neurons

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.16131

Abstract: Poly(ADP‐ribose) polymerase‐1 (PARP1) is a bottleneck that connects different DNA pathways during a DNA damage response. Interestingly, PARP1 has a dualist role in neurons, acting as a neuroprotector and inducer of cell death in distinct… read more here.

Keywords: different dna; memory; dna repair; repair pathways ... See more keywords

Natural transformation-specific DprA coordinate DNA double-strand break repair pathways in heavily irradiated D. radiodurans

Sign Up to like & get
recommendations! Published in 2024 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.01948-23

Abstract: ABSTRACT Deinococcus radiodurans exhibits remarkable survival under extreme conditions, including ionizing radiation, desiccation, and various DNA-damaging agents. It employs unique repair mechanisms, such as single-strand annealing (SSA) and extended synthesis-dependent strand annealing (ESDSA), to efficiently… read more here.

Keywords: radiation; strand; dpra; repair ... See more keywords
Photo from wikipedia

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

Sign Up to like & get
recommendations! Published in 2020 at "Molecular Neurodegeneration"

DOI: 10.1186/s13024-020-00365-9

Abstract: Background The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. The C9ORF72 expansion encodes five dipeptide repeat proteins… read more here.

Keywords: repair pathways; dna; homology directed; dna dsb ... See more keywords
Photo from wikipedia

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer

Sign Up to like & get
recommendations! Published in 2020 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2020.575711

Abstract: Esophageal squamous cell cancer (ESCC) is a common malignancy with a poor 5-year overall survival in China. Altered DNA damage repair (DDR) pathways are associated with a predisposition to cancer and contribute to therapeutic response… read more here.

Keywords: repair pathways; cancer; gene; cell ... See more keywords
Photo from wikipedia

DNA Repair Pathways in Cancer Therapy and Resistance

Sign Up to like & get
recommendations! Published in 2020 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2020.629266

Abstract: DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression… read more here.

Keywords: repair pathways; dna repair; dna; resistance ... See more keywords
Photo from wikipedia

Therapeutic Targeting of DNA Repair Pathways in Pediatric Extracranial Solid Tumors: Current State and Implications for Immunotherapy

Sign Up to like & get
recommendations! Published in 2024 at "Cancers"

DOI: 10.3390/cancers16091648

Abstract: Simple Summary Survival for many pediatric cancers has improved over recent decades. However, for pediatric patients with solid tumors that fail to respond to standard therapies, or relapse after initial response, outcomes generally remain poor,… read more here.

Keywords: dna damage; solid tumors; repair; ddr ... See more keywords

Autophagy Roles in the Modulation of DNA Repair Pathways

Sign Up to like & get
recommendations! Published in 2017 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms18112351

Abstract: Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders including premature aging, neurodegenerative diseases, and cancer. The interchange between these pathways is complex… read more here.

Keywords: repair pathways; dna repair; roles modulation; repair ... See more keywords