Characterization of DNA double‐strand break repair pathways in diffuse large B cell lymphoma
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DOI: 10.1002/mc.22921
Abstract: Efficient DNA repair is indispensable for maintaining genomic integrity in humans. Cancer associated deletions and mutations are mainly due to misrepaired DNA double‐strand breaks (DSBs). Classical nonhomologous end joining (c‐NHEJ) and homologous recombination (HR) are… read more here.
Keywords: lymphoma; repair pathways; dna double; cell ... See more keywords
The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens
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DOI: 10.1093/femsre/fuac035
Abstract: Abstract DNA double-strand breaks require repair or risk corrupting the language of life. To ensure genome integrity and viability, multiple DNA double-strand break repair pathways function in eukaryotes. Two such repair pathways, canonical non-homologous end… read more here.
Keywords: dna repair; filamentous pathogens; repair; repair pathways ... See more keywords
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD
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DOI: 10.1186/s13024-020-00365-9
Abstract: Background The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. The C9ORF72 expansion encodes five dipeptide repeat proteins… read more here.
Keywords: repair pathways; dna; homology directed; dna dsb ... See more keywords
A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer
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DOI: 10.3389/fonc.2020.575711
Abstract: Esophageal squamous cell cancer (ESCC) is a common malignancy with a poor 5-year overall survival in China. Altered DNA damage repair (DDR) pathways are associated with a predisposition to cancer and contribute to therapeutic response… read more here.
Keywords: repair pathways; cancer; gene; cell ... See more keywords
DNA Repair Pathways in Cancer Therapy and Resistance
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DOI: 10.3389/fphar.2020.629266
Abstract: DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression… read more here.
Keywords: repair pathways; dna repair; dna; resistance ... See more keywords
Autophagy Roles in the Modulation of DNA Repair Pathways
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DOI: 10.3390/ijms18112351
Abstract: Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders including premature aging, neurodegenerative diseases, and cancer. The interchange between these pathways is complex… read more here.
Keywords: repair pathways; dna repair; roles modulation; repair ... See more keywords