Surface imprinted bio‐nanocomposites for affinity separation of a cellular DNA repair protein
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23537
Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional DNA repair protein localized in different subcellular compartments. The mechanisms responsible for the highly regulated subcellular localization and “interactomes” of this protein are not fully understood but have… read more here.
Keywords: dna repair; repair protein; bio nanocomposite;
In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107878
Abstract: SUMMARY Programmable RNA editing is gaining momentum as an approach to repair mutations, but its efficiency in repairing endogenous mutant RNA in complex tissue is unknown. Here we apply this approach to the brain and… read more here.
Keywords: repair protein; vivo repair; rna; rna editing ... See more keywords
Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00771
Abstract: We successfully repurpose the DNA repair protein methylguanine methyltransferase (MGMT) as an inducible degron for protein fusions. MGMT is a suicide protein that removes alkyl groups from the O6 position of guanine (O6G) and is… read more here.
Keywords: fusion; degron; repurposing damage; guanine ... See more keywords
Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21127-1
Abstract: Meiotic recombination is a critical process for plant breeding, as it creates novel allele combinations that can be exploited for crop improvement. In wheat, a complex allohexaploid that has a diploid-like behaviour, meiotic recombination between… read more here.
Keywords: homoeologous recombination; repair protein; wheat; mismatch repair ... See more keywords