Diseases Associated with Mutation of Replication and Repair Proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-0529-0_12
Abstract: Alterations in proteins that function in DNA replication and repair have been implicated in the development of human diseases including cancer, premature ageing, skeletal disorders, mental retardation, microcephaly, and neurodegeneration. Drosophila has orthologues of most… read more here.
Keywords: diseases associated; repair proteins; replication repair; associated mutation ... See more keywords
Role of Ku70 in the apoptosis of inflamed dental pulp stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1167-2
Abstract: AimThe study aimed to investigate the effects of DNA repair proteins on cell apoptosis in human DPSCs during inflammation.MethodsLipopolysaccharide (LPS) was used to stimulate inflammation in dental pulp in vivo and in vitro. We identified… read more here.
Keywords: role ku70; dna repair; repair proteins; dpscs ... See more keywords
Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107635
Abstract: Expanded CAG repeats form stem-loop secondary structures that lead to fork stalling and collapse. Previous work has shown that these collapsed forks relocalize to nuclear pore complexes (NPCs) in late S phase in a manner… read more here.
Keywords: sumoylation; dna repair; fork; repair proteins ... See more keywords
Dynamic action of DNA repair proteins as revealed by single molecule techniques: Seeing is believing.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102909
Abstract: DNA repair is a highly dynamic process in which the actual damage recognition process occurs through an amazing dance between the DNA duplex containing the lesion and the DNA repair proteins. Single molecule investigations have… read more here.
Keywords: repair proteins; single molecule; dna repair; dna ... See more keywords
Janus polymer-grafted nanoparticles mimicking membrane repair proteins for the prevention of lipid membrane rupture.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d3nr00395g
Abstract: Plasma membrane rupture often leads to cell damage, especially when there is a lack of membrane repair proteins near the wounds due to genetic mutations in organisms. To efficiently promote the repair of the injured… read more here.
Keywords: membrane repair; repair proteins; polymer; membrane ... See more keywords
Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.753175
Abstract: Proper regulation of neuronal morphological changes is essential for neuronal migration, maturation, synapse formation, and high-order function. Many cytoplasmic proteins involved in the regulation of neuronal microtubules and the actin cytoskeleton have been identified. In… read more here.
Keywords: dna repair; alternative functions; cell cycle; cycle ... See more keywords
Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1131698
Abstract: Mammalian centromeres are generally composed of dispersed repeats and the satellites such as α-satellites in human and major/minor satellites in mouse. Transcription of centromeres by RNA polymerase II is evolutionary conserved and critical for kinetochore… read more here.
Keywords: dna repair; transcription; growing oocytes; repair proteins ... See more keywords
Routine Immunohistochemical Analysis of Mismatch Repair Proteins in Colorectal Cancer—A Prospective Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153730
Abstract: Simple Summary Recognition of a hereditary colorectal cancer (CRC) syndrome is crucial. Our aim was to assess the value of routine immunohistochemistry screening for mismatch repair proteins deficiency in CRC patients under 70 years-old. In… read more here.
Keywords: analysis; colorectal cancer; mismatch repair; repair proteins ... See more keywords
Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins15010004
Abstract: The plasma membrane (PM) protects cells from extracellular threats and supports cellular homeostasis. Some pathogens produce pore-forming toxins (PFTs) that disrupt PM integrity by forming transmembrane pores. High PFT concentrations cause massive damage leading to… read more here.
Keywords: extracellular vesicles; repair proteins; dependent cytolysins; cholesterol dependent ... See more keywords