The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
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DOI: 10.1016/j.celrep.2020.107849
Abstract: SUMMARY Replication-blocking DNA lesions are particularly toxic to proliferating cells because they can lead to chromosome mis-segregation if not repaired prior to mitosis. In this study, we report that ZGRF1 null cells accumulate chromosome aberrations… read more here.
Keywords: dna damage; repair replication; replication blocking; zgrf1 helicase ... See more keywords
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-020-0218-z
Abstract: The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition. BRCA1 partners with BRCA1-associated RING domain protein 1 (BARD1)… read more here.
Keywords: dna repair; repair replication; replication; brca1 bard1 ... See more keywords