CXCR1/2 pathways in paclitaxel-induced neuropathic pain
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DOI: 10.18632/oncotarget.15533
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a type of neuropathic pain that represents a frequent and serious consequence of chemotherapy agents. Over the last years, significant progress has been achieved in elucidating the underlying pathogenesis of… read more here.
Keywords: paclitaxel induced; reparixin; neuropathic pain; cxcr1 ... See more keywords
The effect of reparixin on survival in patients at high risk for in-hospital mortality: a meta-analysis of randomized trials
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DOI: 10.3389/fimmu.2022.932251
Abstract: Introduction A great number of anti-inflammatory drugs have been suggested in the treatment of SARS-CoV-2 infection. Reparixin, a non-competitive allosteric inhibitor of the CXCL8 (IL-8) receptors C-X-C chemokine receptor type 1 (CXCR1) and C-X-C chemokine… read more here.
Keywords: meta analysis; patients high; high risk; mortality ... See more keywords
The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1 low Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.853484
Abstract: A major role for human (h)CXCL8 (interleukin-8) in the pathobiology of myelofibrosis (MF) has been suggested by observations indicating that MF megakaryocytes express increased levels of hCXCL8 and that plasma levels of this cytokine in… read more here.
Keywords: gata1 low; marrow; myelofibrosis; mice ... See more keywords