Trinucleotide CGG Repeat Diseases: An Expanding Field of Polyglycine Proteins?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.843014
Abstract: Microsatellites are repeated DNA sequences of 3–6 nucleotides highly variable in length and sequence and that have important roles in genomes regulation and evolution. However, expansion of a subset of these microsatellites over a threshold… read more here.
Keywords: repeat; cgg repeat; trinucleotide cgg; polyglycine ... See more keywords
Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.750629
Abstract: Repeat diseases, such as fragile X syndrome, myotonic dystrophy, Friedreich ataxia, Huntington disease, spinocerebellar ataxias, and some forms of amyotrophic lateral sclerosis, are caused by repetitive DNA sequences that are expanded in affected individuals. The… read more here.
Keywords: disease; repeat; genetic epigenetic; severity ... See more keywords