Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out‐of‐hospital seizure clusters: Results from a phase 3, open‐label, repeat‐dose safety study
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DOI: 10.1111/epi.17177
Abstract: An exploratory analysis from a long‐term, phase 3, open‐label, repeat‐dose safety study of diazepam nasal spray for acute treatment of seizure clusters assessed the use of a second dose up to 24 hours after the… read more here.
Keywords: repeat dose; dose safety; phase open; safety study ... See more keywords
Twenty-year outcomes after repeat doses of antenatal corticosteroids prior to 32 weeks’ gestation: Follow-up of a randomised clinical trial
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DOI: 10.1371/journal.pmed.1004618
Abstract: Background For women who have received a course of antenatal corticosteroids ≥7 days prior and have ongoing risk of preterm birth within the next 7 days, repeat dose(s) of corticosteroids up to 32 weeks’ gestation… read more here.
Keywords: repeat dose; trial; antenatal corticosteroids; weeks gestation ... See more keywords
Does the repeat dose of gonadotropin-releasing hormone agonist trigger in polycystic ovarian syndrome improve in vitro fertilization cycles outcome? A clinical trial study
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DOI: 10.18502/ijrm.v13i7.7363
Abstract: Abstract Background A repeat dose of Gonadotropin-releasing Hormone (GnRH) agonist could provide long duration of luteinizing hormone (LH) surge and amplitude appropriately. Objective Improvement in oocyte maturity could be obtained by a repeat dose of… read more here.
Keywords: agonist; study; repeat dose; maturity ... See more keywords
The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus Monkey
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DOI: 10.3389/fcvm.2021.587149
Abstract: Purpose: Doxorubicin-related heart failure has been recognized as a serious complication of cancer chemotherapy. This paper describes a cardiovascular safety pharmacology study with chronic dosing of doxorubicin in a non-human primate model designed to characterize… read more here.
Keywords: repeat dose; study; cynomolgus monkey; doxorubicin ... See more keywords
Preclinical Immunogenicity of a 6-Valent GBS Glycoconjugate Vaccine from a Repeat-Dose GLP Toxicology Study
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DOI: 10.3390/vaccines13090952
Abstract: Background/Objectives: Group B Streptococcus (GBS) is a significant cause of perinatal infection in neonates and infants. Complications could include neonatal sepsis and meningitis, preterm birth, stillbirth, or death. Though no GBS vaccine is currently licensed,… read more here.
Keywords: dose glp; gbs; repeat dose; vaccine ... See more keywords