LRRK2‐mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27601
Abstract: Leucine‐rich repeat kinase 2 is a potential therapeutic target for the treatment of Parkinson's disease, and clinical trials of leucine‐rich repeat kinase 2 inhibitors are in development. The objective of this study was to evaluate… read more here.
Keywords: parkinson disease; rich repeat; repeat kinase; leucine rich ... See more keywords
Can Leucine‐Rich Repeat Kinase 2 Inhibition Benefit GBA–Parkinson's Disease?
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28029
Abstract: Lysosomes are cellular organelles with multiple functions that are important in the maintenance of cellular homeostasis. Specifically, lysosomes are primarily catabolic stations that degrade both intracellular contents, including through autophagy, and extracellular contents trafficked through… read more here.
Keywords: sanyal colleagues; disease; repeat kinase; parkinson disease ... See more keywords
The heterozygous R1441C mutation of leucine-rich repeat kinase 2 gene in a Chinese patient with Parkinson disease: A five-year follow-up and literatures review
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2016.12.009
Abstract: BACKGROUND Leucine-rich repeat kinase 2 gene (LRRK2) was recognized associated with both familial and sporadic Parkinson Disease (PD). Seven missense mutations (G2019S, R1441C, R1441G, R1441H, Y1699C, I2020T, N1437H) of it have been confirmed disease- causing.… read more here.
Keywords: kinase gene; leucine rich; disease; repeat kinase ... See more keywords
The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01552
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common genetic risk factor for PD. Elevated LRRK2 kinase… read more here.
Keywords: repeat kinase; leucine rich; parkinson disease; kinase ... See more keywords
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Journal"
DOI: 10.1042/bcj20210383
Abstract: Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to… read more here.
Keywords: repeat kinase; kinase; biology; rich repeat ... See more keywords
Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddw363
Abstract: Parkinson's disease (PD) is characterized by slow, progressive degeneration of dopaminergic neurons in the substantia nigra. The cause of neuronal death in PD is largely unknown, but several genetic loci, including leucine-rich repeat kinase 2… read more here.
Keywords: leucine rich; kinase; repeat kinase; rich repeat ... See more keywords
A Leucine-Rich Repeat Kinase 2 (LRRK2) Pathway Biomarker Characterization Study in Patients with Parkinson's Disease with and without LRRK2 Mutations and Healthy Controls.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13541
Abstract: Increased leucine-rich repeat kinase 2 (LRRK2) kinase activity is an established risk factor for Parkinson's disease (PD), and several LRRK2-kinase inhibitors are in clinical development as potential novel disease modifying therapeutics. This biomarker characterization study… read more here.
Keywords: repeat kinase; leucine rich; kinase; rich repeat ... See more keywords
Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-020-00360-0
Abstract: Background Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with familial forms of late onset Parkinson’s disease (PD), the most common age-related movement disorder. The dysfunction of dopamine transmission contributes to PD-related… read more here.
Keywords: leucine rich; kinase; repeat kinase; rich repeat ... See more keywords
The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.909303
Abstract: Leucine-rich repeat kinase 2 (LRRK2) is one of the most common causative genes in Parkinson’s disease (PD). The complex structure of this multiple domains’ protein determines its versatile functions in multiple physiological processes, including migration,… read more here.
Keywords: repeat kinase; double faceted; role; leucine rich ... See more keywords
WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson’s Disease Monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.892899
Abstract: Both leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are promising targets for the treatment of Parkinson’s disease (PD). Evidence suggests that both proteins are involved in biological pathways involving the lysosome. However, studies to… read more here.
Keywords: repeat kinase; leucine rich; parkinson disease; rich repeat ... See more keywords
Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2017.00005
Abstract: Dominant mutations in leucine-rich repeat kinase 2 (LRRK2) produce the most common inherited form of Parkinson’s disease (PD) but the function of LRRK2 remains poorly understood. The presynaptic role of multiple genes linked to PD… read more here.
Keywords: vesicle; leucine rich; lrrk2; repeat kinase ... See more keywords