Snapshots of urea‐induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4515
Abstract: Protein folding and unfolding is a complex process, underscored by the many proteotoxic diseases associated with misfolded proteins. Mapping pathways from a native structure to an unfolded protein or vice versa, identifying the intermediates, and… read more here.
Keywords: resolution; snapshots urea; structural changes; repeat protein ... See more keywords
Valence-controlled protein conjugation on nanoparticles via re-arrangeable multivalent interactions of tandem repeat protein chains
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06993d
Abstract: Precise control of the number of conjugated proteins on a nanoparticle surface has long been a highly challenging task. Here, we developed a one-pot, purification-free strategy for valency-controlled conjugation of tandem repeat protein chains on… read more here.
Keywords: protein chains; controlled protein; repeat protein; tandem repeat ... See more keywords
Pentatricopeptide repeat protein MTSF3 ensures mitochondrial RNA stability and embryogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac309
Abstract: Gene expression in plant mitochondria is predominantly governed at the post-transcriptional level and relies mostly on nuclear-encoded proteins. However, the protein factors involved and the underlying molecular mechanisms are still not well understood. Here, we… read more here.
Keywords: pentatricopeptide repeat; stability; repeat protein; mtsf3 ... See more keywords
Expanded Function of the P-Type Pentatricopeptide Repeat Protein ATP4 in RNA Editing
Sign Up to like & getrecommendations! Published in 2020 at "Plant Physiology"
DOI: 10.1104/pp.20.01406
Abstract: Chloroplasts are semiautonomous organelles that retain their own genomes derived from their cyanobacterial ancestors, but with reduced size and gene number. However, chloroplast genes cannot function autonomously. Instead, nucleus-encoded factors are required for all steps… read more here.
Keywords: repeat protein; expanded function; function type; type pentatricopeptide ... See more keywords
Inferring repeat-protein energetics from evolutionary information
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DOI: 10.1371/journal.pcbi.1005584
Abstract: Natural protein sequences contain a record of their history. A common constraint in a given protein family is the ability to fold to specific structures, and it has been shown possible to infer the main… read more here.
Keywords: protein; inferring repeat; energetics evolutionary; evolutionary information ... See more keywords
Peptide binding affinity redistributes preassembled repeat protein fragments
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0355
Abstract: Abstract Designed armadillo repeat proteins (dArmRPs) are modular peptide binders composed of N- and C-terminal capping repeats Y and A and a variable number of internal modules M that each specifically recognize two amino acids… read more here.
Keywords: protein; peptide; affinity; target peptide ... See more keywords
Folding and Evolution of a Repeat Protein on the Ribosome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.851038
Abstract: Life on earth is the result of the work of proteins, the cellular nanomachines that fold into elaborated 3D structures to perform their functions. The ribosome synthesizes all the proteins of the biosphere, and many… read more here.
Keywords: folding evolution; ribosome folding; repeat protein; protein ribosome ... See more keywords
A Plastid-Bound Ankyrin Repeat Protein Controls Gametophyte and Early Embryo Development in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.767339
Abstract: Proplastids are essential precursors for multi-fate plastid biogenesis, including chloroplast differentiation, a powerhouse for photosynthesis in plants. Arabidopsis ankyrin repeat protein (AKRP, AT5G66055) is a plastid-localized protein with a putative function in plastid differentiation and… read more here.
Keywords: plastid; embryo development; akrp; repeat protein ... See more keywords
Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner
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DOI: 10.3390/biom11060827
Abstract: The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein β-catenin acts as the signal… read more here.
Keywords: repeat protein; dissociation; repeat; molecular recognition ... See more keywords