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   Articles with "repeat protein" as a keyword



Snapshots of urea‐induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution

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recommendations! Published in 2022 at "Protein Science"

DOI: 10.1002/pro.4515

Abstract: Protein folding and unfolding is a complex process, underscored by the many proteotoxic diseases associated with misfolded proteins. Mapping pathways from a native structure to an unfolded protein or vice versa, identifying the intermediates, and… read more here.

Keywords: resolution; snapshots urea; structural changes; repeat protein ... See more keywords

Valence-controlled protein conjugation on nanoparticles via re-arrangeable multivalent interactions of tandem repeat protein chains

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recommendations! Published in 2022 at "Chemical Science"

DOI: 10.1039/d1sc06993d

Abstract: Precise control of the number of conjugated proteins on a nanoparticle surface has long been a highly challenging task. Here, we developed a one-pot, purification-free strategy for valency-controlled conjugation of tandem repeat protein chains on… read more here.

Keywords: protein chains; controlled protein; repeat protein; tandem repeat ... See more keywords

Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk

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recommendations! Published in 2024 at "Biochemical Journal"

DOI: 10.1042/bcj20230477

Abstract: Leucine-rich repeat protein kinase 2 (LRRK2) is a multi-domain protein encompassing two of biology's most critical molecular switches, a kinase and a GTPase, and mutations in LRRK2 are key players in the pathogenesis of Parkinson's… read more here.

Keywords: rich repeat; leucine rich; helix; protein ... See more keywords

Pentatricopeptide repeat protein MTSF3 ensures mitochondrial RNA stability and embryogenesis.

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recommendations! Published in 2022 at "Plant physiology"

DOI: 10.1093/plphys/kiac309

Abstract: Gene expression in plant mitochondria is predominantly governed at the post-transcriptional level and relies mostly on nuclear-encoded proteins. However, the protein factors involved and the underlying molecular mechanisms are still not well understood. Here, we… read more here.

Keywords: pentatricopeptide repeat; stability; repeat protein; mtsf3 ... See more keywords
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Expanded Function of the P-Type Pentatricopeptide Repeat Protein ATP4 in RNA Editing

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recommendations! Published in 2020 at "Plant Physiology"

DOI: 10.1104/pp.20.01406

Abstract: Chloroplasts are semiautonomous organelles that retain their own genomes derived from their cyanobacterial ancestors, but with reduced size and gene number. However, chloroplast genes cannot function autonomously. Instead, nucleus-encoded factors are required for all steps… read more here.

Keywords: repeat protein; expanded function; function type; type pentatricopeptide ... See more keywords

Inferring repeat-protein energetics from evolutionary information

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recommendations! Published in 2017 at "PLoS Computational Biology"

DOI: 10.1371/journal.pcbi.1005584

Abstract: Natural protein sequences contain a record of their history. A common constraint in a given protein family is the ability to fold to specific structures, and it has been shown possible to infer the main… read more here.

Keywords: protein; inferring repeat; energetics evolutionary; evolutionary information ... See more keywords

Peptide binding affinity redistributes preassembled repeat protein fragments

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recommendations! Published in 2019 at "Biological Chemistry"

DOI: 10.1515/hsz-2018-0355

Abstract: Abstract Designed armadillo repeat proteins (dArmRPs) are modular peptide binders composed of N- and C-terminal capping repeats Y and A and a variable number of internal modules M that each specifically recognize two amino acids… read more here.

Keywords: protein; peptide; affinity; target peptide ... See more keywords

Folding and Evolution of a Repeat Protein on the Ribosome

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.851038

Abstract: Life on earth is the result of the work of proteins, the cellular nanomachines that fold into elaborated 3D structures to perform their functions. The ribosome synthesizes all the proteins of the biosphere, and many… read more here.

Keywords: folding evolution; ribosome folding; repeat protein; protein ribosome ... See more keywords

A Plastid-Bound Ankyrin Repeat Protein Controls Gametophyte and Early Embryo Development in Arabidopsis thaliana

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2022.767339

Abstract: Proplastids are essential precursors for multi-fate plastid biogenesis, including chloroplast differentiation, a powerhouse for photosynthesis in plants. Arabidopsis ankyrin repeat protein (AKRP, AT5G66055) is a plastid-localized protein with a putative function in plastid differentiation and… read more here.

Keywords: plastid; embryo development; akrp; repeat protein ... See more keywords
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Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner

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recommendations! Published in 2021 at "Biomolecules"

DOI: 10.3390/biom11060827

Abstract: The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein β-catenin acts as the signal… read more here.

Keywords: repeat protein; dissociation; repeat; molecular recognition ... See more keywords

Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture

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recommendations! Published in 2025 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms26115236

Abstract: Designed ankyrin repeat protein (DARPin) Ec1, a small scaffold protein (18 kDa), binds with high affinity the epithelial cell adhesion molecule (EpCAM) that is overexpressed in several carcinomas. To enhance the targeted delivery of cytotoxic… read more here.

Keywords: abd; ec1; effect; repeat protein ... See more keywords