Context-Dependent Energetics of Loop Extensions in a Family of Tandem-Repeat Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2018.03.038
Abstract: Consensus-designed tetratricopeptide repeat proteins are highly stable, modular proteins that are strikingly amenable to rational engineering. They therefore have tremendous potential as building blocks for biomaterials and biomedicine. Here, we explore the possibility of extending… read more here.
Keywords: repeat proteins; energetics loop; repeat; dependent energetics ... See more keywords
Evolution and folding of repeat proteins
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204131119
Abstract: Significance Protein sequences change over evolutionary times. The fixation of these changes is coupled to the protein’s capability to properly explore conformational space and perform biological functions. Repeat proteins are privileged systems to understand the… read more here.
Keywords: folding repeat; evolution folding; repeat; repeat proteins ... See more keywords
Serine-rich repeat proteins from gut microbes
Sign Up to like & getrecommendations! Published in 2019 at "Gut Microbes"
DOI: 10.1080/19490976.2019.1602428
Abstract: ABSTRACT Serine-rich repeat proteins (SRRPs) have emerged as an important group of cell surface adhesins found in a growing number of Gram-positive bacteria. Studies focused on SRRPs from streptococci and staphylococci demonstrated that these proteins… read more here.
Keywords: gut microbes; rich repeat; repeat proteins; serine rich ... See more keywords
Three new pentatricopeptide repeat proteins facilitate the splicing of mitochondrial transcripts and complex I biogenesis in Arabidopsis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/ery275
Abstract: Three nuclear encoded multi-functional pentatricopeptide repeat proteins localizing in the mitochondrion are involved in splicing of a cohort of mitochondrial group II introns and thereby required for complex I biogenesis. read more here.
Keywords: pentatricopeptide repeat; complex biogenesis; three new; repeat proteins ... See more keywords
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq3215
Abstract: Arginine-rich dipeptide repeat proteins (R-DPRs), abnormal translational products of a GGGGCC hexanucleotide repeat expansion in C9ORF72, play a critical role in C9ORF72-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the most common genetic form… read more here.
Keywords: rich dipeptide; repeat proteins; repeat; arginine rich ... See more keywords
Structural and Functional Analysis of Peptides Derived from KEX2-Processed Repeat Proteins in Agaricomycetes Using Reverse Genetics and Peptidomics
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02021-22
Abstract: Two recent bioinformatics studies have demonstrated that KEX2-processed repeat proteins are widespread in the fungal kingdom. However, despite the prevalence of KEPs in fungal genomes, only few KEP-derived peptides have been detected and studied so… read more here.
Keywords: repeat proteins; processed repeat; kep derived; kex2 processed ... See more keywords
Squid-Inspired Tandem Repeat Proteins: Functional Fibers and Films
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00069
Abstract: Production of repetitive polypeptides that comprise one or more tandem copies of a single unit with distinct amorphous and ordered regions have been an interest for the last couple of decades. Their molecular structure provides… read more here.
Keywords: repeat proteins; squid inspired; tandem repeat; inspired tandem ... See more keywords
Pas de Trois: An Overview of Penta-, Tetra-, and Octo-Tricopeptide Repeat Proteins From Chlamydomonas reinhardtii and Their Role in Chloroplast Gene Expression
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.775366
Abstract: Penta-, Tetra-, and Octo-tricopeptide repeat (PPR, TPR, and OPR) proteins are nucleus-encoded proteins composed of tandem repeats of 35, 34, and 38–40 amino acids, respectively. They form helix-turn-helix structures that interact with mRNA or other… read more here.
Keywords: repeat proteins; ppr proteins; gene expression; repeat ... See more keywords
C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.51685
Abstract: Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear. Karyopherins, including importin β and its cargo adaptors,… read more here.
Keywords: repeat proteins; c9orf72 arginine; repeat; arginine ... See more keywords