Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in drosophila models of C9orf72-linked ALS/FTD.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac298
Abstract: The abnormal expansion of GGGGCC hexanucleotide repeats within the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The accumulation of GGGGCC repeat-containing RNAs as RNA foci,… read more here.
Keywords: ggggcc repeat; rna; repeat; repeat rna ... See more keywords
Abstract A039: Repeat RNA mediated disruption of cellular plasticity in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.pancreatic24-a039
Abstract: Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimics viral-like responses with implications for tumor cell state and the surrounding microenvironment. To better understand the relationship of repeat RNAs in human PDAC, we… read more here.
Keywords: repeat; cancer; repeat rna; cell ... See more keywords
Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.25293
Abstract: The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic… read more here.
Keywords: major satellite; satellite repeat; rna; repeat rna ... See more keywords