Interaction kinetics reveal distinct properties of conformational ensembles of three‐repeat and four‐repeat tau proteins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14339
Abstract: Tau protein is an intrinsically disordered protein. Its physiological state is best described as a conformational ensemble (CE) of metastable structures interconverting on the local and molecular scale. The monoclonal antibody DC39C recognizes a linear… read more here.
Keywords: tau proteins; tau; three repeat; interaction kinetics ... See more keywords
A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24447
Abstract: Human tauopathies represent a heterogeneous group of neurodegenerative disorders characterized by distinct clinical features, typical histopathological structures, and defined ratio(s) of three‐repeat and four‐repeat tau isoforms within pathological aggregates. How the optional microtubule‐binding repeat of… read more here.
Keywords: repeat; three four; pathology; repeat tau ... See more keywords