Assessment of the 4‐week repeated‐dose oral toxicity and genotoxicity of GHX02
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3902
Abstract: Herbal medicines are widely utilized for disease prevention and health promotion. GHX02 consists of mixtures including Gwaruin (Trichosanthes kirilowii), Haengin (Prunus armeniaca), Hwangryeon (Coptis japonica) and Hwangkeum (Scutellaria baicalensis). It has been purported to have… read more here.
Keywords: study; toxicity; dose oral; repeated dose ... See more keywords
Acute and single repeated dose effects of low concentrations of chlorpyrifos, diuron, and their combination on chicken
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-1313-y
Abstract: This study investigated the acute and single repeated dose effects of low concentrations of chlorpyrifos, diuron, and their mixture to chicken. The effects were determined as biological response (chicken behavior); physiological response (body weight, gaining… read more here.
Keywords: single repeated; acute single; repeated dose; low concentrations ... See more keywords
Single- and repeated-dose 28-day oral toxicity study of MDM hydantoin in Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicological research"
DOI: 10.1007/s43188-020-00055-0
Abstract: 1-(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione (MDM hydantoin) is a commonly used antiseptic preservative in cosmetics. However, limited toxicity information data are available for this chemical. The aim of this study was to obtain toxicity data for MDM hydantoin through… read more here.
Keywords: toxicity study; mdm hydantoin; toxicity; repeated dose ... See more keywords
Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65817-0
Abstract: A microfluidic multi-organ chip emulates the tissue culture microenvironment, enables interconnection of organ equivalents and overcomes interspecies differences, making this technology a promising and powerful tool for preclinical drug screening. In this study, we established… read more here.
Keywords: microfluidic chip; chip based; liver; drug ... See more keywords
Preclinical Safety Evaluation: Acute and Repeated-Dose Toxicity of a New Intranasal Recombinant Vector Vaccine TB/FLU-04L Against Tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1771-5985
Abstract: BACKGROUND Vaccination against tuberculosis is one of the most successful medical measures to reduce morbidity and mortality. The BCG vaccine has been in use for more than 100 years, but its efficacy is still controversial.… read more here.
Keywords: toxicity; toxicity study; flu 04l; dose toxicity ... See more keywords
28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance
Sign Up to like & getrecommendations! Published in 2022 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2022.2036183
Abstract: Abstract Ayurvedic medicines are widely employed globally for prophylaxis and treatment of a variety of diseases. Coronil is a tri-herbal medicine, constituted with the traditional herbs, Tinospora cordifolia, Withania somnifera and Ocimum sanctum, with known… read more here.
Keywords: sprague dawley; coronil; day; day repeated ... See more keywords
Brain regional pharmacokinetics following the oral administration of curcumagalactomannosides and its relation to cognitive function.
Sign Up to like & getrecommendations! Published in 2021 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2021.1913951
Abstract: OBJECTIVE Though a number of bioavailable formulations of curcuminoids have been reported and available commercially as nutraceuticals for brain health, systematic informations on their blood-brain-barrier permeability and brain tissue distribution have not been reported. The… read more here.
Keywords: administration; repeated dose; cgm; brain regional ... See more keywords
Repeated Dose Toxicity Study and Developmental and Reproductive Toxicology Studies of a Respiratory Syncytial Virus Candidate Vaccine in Rabbits and Rats
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Toxicology"
DOI: 10.1177/1091581820985782
Abstract: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, and vaccines are needed to treat young children and older adults. One of GSK’s candidate vaccines for RSV contains recombinant RSVPreF3… read more here.
Keywords: respiratory syncytial; syncytial virus; rsvpref3 vaccine; repeated dose ... See more keywords
Effects of Mexican Ganoderma lucidum extracts on liver, kidney, and the gut microbiota of Wistar rats: A repeated dose oral toxicity study
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283605
Abstract: Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum (Gl), a medicinal mushroom, cultivated on oak sawdust (Gl-1) or oak sawdust plus acetylsalicylic acid (Gl-2, ASA), have been shown to exert antioxidant, hypocholesterolemic,… read more here.
Keywords: gut microbiota; kidney; toxicity; ganoderma lucidum ... See more keywords
Toxicological Assessment of Bromochlorophene: Single and Repeated-Dose 28-Day Oral Toxicity, Genotoxicity, and Dermal Application in Sprague–Dawley Rats
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.690141
Abstract: Bromochlorophene (BCP) has shown good properties in sterilization and antibacterial activity and is widely used as a household chemical. We evaluated the genotoxicity, single and repeated-dose 28-day oral toxicity, and dermal application of a BCP… read more here.
Keywords: toxicity; dose day; bcp; repeated dose ... See more keywords
Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126615
Abstract: The risk-characterization of chemicals requires the determination of repeated-dose toxicity (RDT). This depends on two main outcomes: the no-observed-adverse-effect level (NOAEL) and the lowest-observed-adverse-effect level (LOAEL). These endpoints are fundamental requirements in several regulatory frameworks,… read more here.
Keywords: systemic organ; organ specific; sub chronic; toxicity ... See more keywords