Assessment of the 4‐week repeated‐dose oral toxicity and genotoxicity of GHX02
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3902
Abstract: Herbal medicines are widely utilized for disease prevention and health promotion. GHX02 consists of mixtures including Gwaruin (Trichosanthes kirilowii), Haengin (Prunus armeniaca), Hwangryeon (Coptis japonica) and Hwangkeum (Scutellaria baicalensis). It has been purported to have… read more here.
Keywords: study; toxicity; dose oral; repeated dose ... See more keywords
An evaluation of the genotoxicity and 90‐day repeated dose oral toxicity in rats of Porphyridium purpureum
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4665
Abstract: Interest in microalgae products for use in food is increasing, as demands for sustainable and cost‐effective food choices grow due to the escalating global population and increase in climate‐related struggles with agriculture. Toxicological assessments of… read more here.
Keywords: repeated dose; oral toxicity; dose oral; day repeated ... See more keywords
Acute and single repeated dose effects of low concentrations of chlorpyrifos, diuron, and their combination on chicken
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-1313-y
Abstract: This study investigated the acute and single repeated dose effects of low concentrations of chlorpyrifos, diuron, and their mixture to chicken. The effects were determined as biological response (chicken behavior); physiological response (body weight, gaining… read more here.
Keywords: single repeated; acute single; repeated dose; low concentrations ... See more keywords
Single- and repeated-dose 28-day oral toxicity study of MDM hydantoin in Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicological research"
DOI: 10.1007/s43188-020-00055-0
Abstract: 1-(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione (MDM hydantoin) is a commonly used antiseptic preservative in cosmetics. However, limited toxicity information data are available for this chemical. The aim of this study was to obtain toxicity data for MDM hydantoin through… read more here.
Keywords: toxicity study; mdm hydantoin; toxicity; repeated dose ... See more keywords
Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents
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DOI: 10.1038/s41598-020-65817-0
Abstract: A microfluidic multi-organ chip emulates the tissue culture microenvironment, enables interconnection of organ equivalents and overcomes interspecies differences, making this technology a promising and powerful tool for preclinical drug screening. In this study, we established… read more here.
Keywords: microfluidic chip; chip based; liver; drug ... See more keywords
Preclinical Safety Evaluation: Acute and Repeated-Dose Toxicity of a New Intranasal Recombinant Vector Vaccine TB/FLU-04L Against Tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1771-5985
Abstract: BACKGROUND Vaccination against tuberculosis is one of the most successful medical measures to reduce morbidity and mortality. The BCG vaccine has been in use for more than 100 years, but its efficacy is still controversial.… read more here.
Keywords: toxicity; toxicity study; flu 04l; dose toxicity ... See more keywords
28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance
Sign Up to like & getrecommendations! Published in 2022 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2022.2036183
Abstract: Abstract Ayurvedic medicines are widely employed globally for prophylaxis and treatment of a variety of diseases. Coronil is a tri-herbal medicine, constituted with the traditional herbs, Tinospora cordifolia, Withania somnifera and Ocimum sanctum, with known… read more here.
Keywords: sprague dawley; coronil; day; day repeated ... See more keywords
Repeated dose toxicity studies of Trichostatin A in Swiss albino mice through oral and intravenous route of administration with special emphasis on genotoxicity
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DOI: 10.1080/01480545.2024.2336521
Abstract: Abstract Intravenous and oral 14 d repeated dose toxicity studies of Trichostatin A (TSA) were carried out in Swiss albino mice using low, intermediate, and high doses. Intravenous doses were 10, 25, and 50 μg/kg b.w while… read more here.
Keywords: repeated dose; dose toxicity; toxicity studies; administration ... See more keywords
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats
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DOI: 10.1080/01480545.2024.2427766
Abstract: Abstract Tolypocladium sinense is a new asexual strain isolated from natural Cordyceps sinensis. The mycelium produced by its fermentation culture has similar chemical components and pharmacological effects to C. sinensis. T. sinense soft capsule is… read more here.
Keywords: repeated dose; dose toxicity; soft capsules; toxicity ... See more keywords
Brain regional pharmacokinetics following the oral administration of curcumagalactomannosides and its relation to cognitive function.
Sign Up to like & getrecommendations! Published in 2021 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2021.1913951
Abstract: OBJECTIVE Though a number of bioavailable formulations of curcuminoids have been reported and available commercially as nutraceuticals for brain health, systematic informations on their blood-brain-barrier permeability and brain tissue distribution have not been reported. The… read more here.
Keywords: administration; repeated dose; cgm; brain regional ... See more keywords
Repeated-dose behavioral intervention to reduce opioid overdose among overdose survivors with opioid use disorder: A two-site phase III randomized controlled trial.
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DOI: 10.1111/add.70252
Abstract: BACKGROUND AND AIMS The emergence of fentanyl in the street market for opioids has limited the benefits of some interventions to manage opioid overdose; thus, preventing the occurrence of opioid overdose is essential. We tested… read more here.
Keywords: repeated dose; opioid overdose; opioid use; intervention ... See more keywords