Repeated toluene exposure alters the synaptic transmission of layer 5 medial prefrontal cortex.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2019.02.002
Abstract: Toluene is an organic solvent commonly misused by inhalation among adolescents to experience psychoactive effects. Repeated toluene exposure produces several cognitive deficits, including working memory impairment in which the medial prefrontal cortex (mPFC) plays a… read more here.
Keywords: medial prefrontal; toluene exposure; repeated toluene; synaptic transmission ... See more keywords
Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.114980
Abstract: Toluene can be intentionally misused by adolescents to experience psychoactive effects. Toluene has a complex mechanism of action and broad behavioral effects, among which memory impairment is reported consistently. We have previously reported that repeated… read more here.
Keywords: hyperexcitability; toluene inhalation; memory impairment; repeated toluene ... See more keywords