Effectiveness of a Quality Improvement Intervention on Reperfusion Treatment for Patients With Acute Ischemic Stroke: A Stepped-Wedge Cluster Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2023.16465
Abstract: Key Points Question What is the effect of a problem-oriented, culturally adapted, targeted quality improvement intervention on reperfusion therapy, including intravenous thrombolysis or endovascular thrombectomy, for acute ischemic stroke in China? Findings In this stepped-wedge… read more here.
Keywords: acute ischemic; reperfusion; ischemic stroke; quality improvement ... See more keywords
Safety and Efficacy of Intra-arterial Urokinase After Failed, Unsuccessful, or Incomplete Mechanical Thrombectomy in Anterior Circulation Large-Vessel Occlusion Stroke.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.4192
Abstract: Importance Achieving complete reperfusion is a key determinant of good outcome in patients treated with mechanical thrombectomy (MT). However, data on treatments geared toward improving reperfusion after incomplete MT are sparse. Objective To determine whether… read more here.
Keywords: mechanical thrombectomy; arterial urokinase; reperfusion; intra arterial ... See more keywords
Trends in Reperfusion Therapy for In-Hospital Ischemic Stroke in the Endovascular Therapy Era.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2020.3362
Abstract: Importance A significant proportion of acute ischemic strokes occur while patients are hospitalized. Limited contemporary data exist on the utilization rates of intravenous thrombolysis or endovascular therapy for in-hospital stroke. Objective To use a national… read more here.
Keywords: thrombolysis; hospital stroke; hospital; endovascular therapy ... See more keywords
Platelet Membrane-fused Circulating Extracellular Vesicles Protect the Heart from Ischemia/reperfusion Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300052
Abstract: Myocardial ischemia/reperfusion injury (I/RI) may potentiate cardiac remodeling and heart failure, while effective therapies for I/RI remain lacking. Circulating extracellular vesicles (EV) have great potential to protect against I/RI. However, effective delivery of EV in… read more here.
Keywords: reperfusion; delivery; heart; membrane ... See more keywords
Parenchymal Hemorrhage Rate Is Associated with Time to Reperfusion and Outcome
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DOI: 10.1002/ana.26478
Abstract: Despite a 90% reperfusion rate, only 50% of patients with anterior circulation large vessel occlusion‐related acute ischemic stroke (LVO‐AIS) have a functional recovery at 3 months. Parenchymal hematoma (PH) is a predictor of poor outcome after… read more here.
Keywords: outcome; reperfusion; rate; parenchymal hemorrhage ... See more keywords
Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient‐Level Analysis of EXTEND‐IA Trials and SELECT Prospective Cohort
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26587
Abstract: Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both infarct growth and edema are plausible mediators of clinical benefit with reperfusion. We aimed to quantify these mediators and their interrelationship. read more here.
Keywords: mediation successful; reperfusion; infarct growth; successful reperfusion ... See more keywords
Current trends in utilization of fibrinolytic‐based reperfusion strategies and bleeding outcomes in ST‐elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.29094
Abstract: The COVID-19 (SARS-CoV-2 virus) pandemic has unmasked several challenges for patients with ST-elevation myocardial infarction (STEMI) in the United States. Standard of care primary percutaneous coronary intervention (PPCI) has suffered system delays. There has been… read more here.
Keywords: reperfusion strategies; utilization; myocardial infarction; reperfusion ... See more keywords
Memantine protects against ischemia/reperfusion‐induced brain endothelial permeability
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DOI: 10.1002/iub.1729
Abstract: Increased transendothelial permeability and subsequent blood–brain barrier damage play a key role in the pathological progression of human brain ischemia and secondary reperfusion. Memantine is a licensed drug providing clinically relevant efficacy in patients with… read more here.
Keywords: endothelial permeability; reperfusion; expression; brain ... See more keywords
Inhibition of the LncRNA Gpr19 attenuates ischemia‐reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR‐324‐5p/Mtfr1 axis
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2187
Abstract: Reperfusion therapy after acute myocardial infarction (AMI) can effectively restore the blood supply and nutritional support of ischemic myocardium and save the dying myocardium. However, myocardial ischaemia‐reperfusion (I/R) injury has become a new threat to… read more here.
Keywords: apoptosis; reperfusion; gpr19; injury ... See more keywords
Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF‐κB p65, and cleaved caspase‐3 expressions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23046
Abstract: Ischemia/reperfusion injury (IRI) during kidney transplantation is a serious clinical problem with a high mortality rate and a lack of therapy. Therefore, there is a need to improve the ability of the kidney to tolerate… read more here.
Keywords: ikk p65; effect vinpocetine; nadph oxidase; vinpocetine ... See more keywords
The protective effects of trimetazidine against ovary ischemia–reperfusion injury via the TLR4/Nf‐kB signal pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23114
Abstract: Late diagnosis and treatment of ovarian ischemia can lead to worsening of ischemia, irreversible damage to ovarian functions and infertility. In this process, there is no approved medical treatment that can reduce the negative effects… read more here.
Keywords: ischemia; reperfusion; group ischemia; tmz ... See more keywords