An Injectable Dual-Function Hydrogel Protects Against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium.
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DOI: 10.1002/advs.202105408
Abstract: Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective strategy for treating MI due to the multiple… read more here.
Keywords: ischemia reperfusion; reperfusion injury; injury; function ... See more keywords
Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis
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DOI: 10.1002/advs.202204697
Abstract: Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic acid (3‐HAA) and quinolinic… read more here.
Keywords: kynurenine pathway; reperfusion injury; exacerbates liver; hepatic ischemia ... See more keywords
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)
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DOI: 10.1002/advs.202370079
Abstract: Malic Enzyme 1 In article number 2205436, Xuexian Fang, Fudi Wang, and co‐workers discover Malic Enzyme 1 (ME1) as a novel ferroptosis inhibitory gene, which protects the liver function against ischemia/reperfusion (I/R) injury. The design… read more here.
Keywords: reperfusion injury; ischemia reperfusion; injury; malic enzyme ... See more keywords
Knockdown of XIST up‐regulates 263294miR‐340‐5p to relieve myocardial ischaemia–reperfusion injury via inhibiting cyclin D1
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DOI: 10.1002/ehf2.13766
Abstract: Long non‐coding RNAs (lncRNAs) are known to participate in various human diseases, while the role of X inactive‐specific transcript (XIST) binding microRNA‐340‐5p (miR‐340‐5p) remains seldom studied. We aim to identify the role of the XIST/miR‐340‐5p/cyclin… read more here.
Keywords: xist; ischaemia reperfusion; reperfusion injury; myocardial ischaemia ... See more keywords
TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
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DOI: 10.1002/hep.32015
Abstract: Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury… read more here.
Keywords: interacting protein; ischemia reperfusion; reperfusion injury; injury ... See more keywords
PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation.
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DOI: 10.1002/hep.32384
Abstract: BACKGROUND & AIMS p21 activated kinase 4 (PAK4), an oncogenic protein, has emerged as a promising target for anti-cancer drug development. Its role in oxidative stress conditions, however, remains elusive. We investigated the effects of… read more here.
Keywords: pak4; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Inhibited histone deacetylase 3 ameliorates myocardial ischemia–reperfusion injury in a rat model by elevating microRNA‐19a‐3p and reducing cyclin‐dependent kinase 2
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DOI: 10.1002/iub.2402
Abstract: Over the years, the roles of microRNAs (miRNAs) and histone deacetylase 3 (HDAC3) in human diseases have been investigated. This study focused on the effect of miR‐19a‐3p and HDAC3 in myocardial ischemia–reperfusion (I/R) injury (MIRI)… read more here.
Keywords: cyclin dependent; myocardial ischemia; histone deacetylase; dependent kinase ... See more keywords
MicroRNA‐454 modulates the oxidative stress and neuronal apoptosis after cerebral ischemia/reperfusion injury via targeting NADPH oxidase 4 (NOX4)
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DOI: 10.1002/jbt.23153
Abstract: To investigate the function of miR‐454 in ischemic stroke, this study was carried out. Cerebral ischemia/reperfusion (I/R) injury animal model and a SHSY5Y cell culture model of oxygen‐glucose deprivation/reoxygenation (OGD/R) were constructed. The effects of… read more here.
Keywords: reperfusion injury; mir 454; cerebral ischemia; injury ... See more keywords
Gentiopicroside enhances the protective effect of trimetazidine against myocardial ischemia-reperfusion injury via the AMPK/NLRP3 inflammasome signaling.
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DOI: 10.1002/jbt.23366
Abstract: Myocardial ischemia-reperfusion injury (MI/R) leads to the inevitable clinical consequences of myocardial infarction and subsequent heart failure. Trimetazidine (TMZ), an anti-ischemic agent, exerts protective potential in MI/R but had limited efficacy for some patients. Here… read more here.
Keywords: reperfusion injury; myocardial ischemia; tmz; injury ... See more keywords
Ginkgetin aglycone attenuates the apoptosis and inflammation response through nuclear factor‐kB signaling pathway in ischemic‐reperfusion injury
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DOI: 10.1002/jcb.28086
Abstract: Acute myocardial infarction (AMI) is one of the most threaten disease in the world. Ginkgetin aglycone (GA) was a new kind of Ginkgo biloba, involved in various diseases, including kidney injury and acute pancreatitis. However,… read more here.
Keywords: reperfusion injury; ginkgetin aglycone; injury; ischemic reperfusion ... See more keywords
MicroRNA‐194 overexpression protects against hypoxia/reperfusion‐induced HK‐2 cell injury through direct targeting Rheb
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DOI: 10.1002/jcb.28114
Abstract: Renal ischemia‐reperfusion injury, a major cause of renal failure, always leads to acute kidney injury and kidney fibrosis. MicroRNAs (miRs) have been reported to be associated with renal ischemia‐reperfusion injury. miR‐194 was downregulated following renal… read more here.
Keywords: renal ischemia; ischemia reperfusion; reperfusion injury; injury ... See more keywords