Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13467
Abstract: B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 and HIV or with… read more here.
Keywords: frequency; silico reconstitution; repertoire; bcr ... See more keywords
Manipulative repertoire of bonobos (Pan paniscus) in spontaneous feeding situation
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Primatology"
DOI: 10.1002/ajp.23383
Abstract: Comparative behavioral studies of hand use amongst primate species, including humans, have been central in research on evolutionary mechanisms. In particular, the manipulative abilities of our closest relatives, the chimpanzee (Pan troglodytes), have been widely… read more here.
Keywords: repertoire bonobos; bonobos pan; spontaneous feeding; repertoire ... See more keywords
T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications
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DOI: 10.1002/cac2.12074
Abstract: T cells, which are involved in adaptive immunity, are essential in the elimination of tumor cells. Mature T cells can specifically recognize the antigen on the major histocompatibility complex (MHC) molecule through T‐cell receptors (TCR).… read more here.
Keywords: methodology; analysis; repertoire; tcr repertoire ... See more keywords
Evidence of a skewed T‐cell repertoire in patients with light chain amyloidosis
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DOI: 10.1002/hon.2281
Abstract: Keywords: light-chain amyloidosis; T-cell receptor repertoire; regulatory T-cells; flow cytometry; spectratyping; CDR3 read more here.
Keywords: repertoire; cell; chain amyloidosis; light chain ... See more keywords
T Cell Receptor Repertoire Sequencing.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0904-0_1
Abstract: The status of T cell receptors (TCRs) repertoire is associated with the occurrence and progress of various diseases and can be used in monitoring the immune responses, predicting the prognosis of disease and other medical… read more here.
Keywords: cell receptor; repertoire sequencing; biology; repertoire ... See more keywords
Using High-Throughput Sequencing to Characterize the Development of the Antibody Repertoire During Infections: A Case Study of HIV-1.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-72077-7_12
Abstract: High throughput sequencing (HTS) approaches have only recently been applied to describing the antibody/B-cell repertoire in fine detail, but these data sets have already become critical to the design of vaccines and therapeutics, and monitoring… read more here.
Keywords: case study; antibody; repertoire; throughput sequencing ... See more keywords
On being the right size: antibody repertoire formation in the mouse and human
Sign Up to like & getrecommendations! Published in 2017 at "Immunogenetics"
DOI: 10.1007/s00251-017-1049-8
Abstract: The immune systems of all mammals include populations of B cells producing antibodies with incredibly diverse specificities. Repertoire diversity has been described as the “miracle of immunology,” and it was long thought to be the… read more here.
Keywords: antibody; size; repertoire formation; repertoire ... See more keywords
Peripheral blood T-cell receptor repertoire as a predictor of clinical outcomes in gastrointestinal cancer patients treated with PD-1 inhibitor
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02562-4
Abstract: Identifying valid biomarkers for patient selection impressively promotes the success of anti-PD-1 therapy. However, the unmet need for biomarkers in gastrointestinal (GI) cancers remains significant. We aimed to explore the predictive value of the circulating… read more here.
Keywords: clinical outcomes; diversity; cell receptor; repertoire ... See more keywords
Full-repertoire comparison of the microscopic objects composing the human gut microbiome with sequenced and cultured communities
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Microbiology"
DOI: 10.1007/s12275-020-9365-3
Abstract: The study of the human gut microbiome is essential in microbiology and infectious diseases as specific alterations in the gut microbiome might be associated with various pathologies, such as chronic inflammatory disease, intestinal infection and… read more here.
Keywords: human gut; composing human; gut microbiome; microbiology ... See more keywords
Low T-Cell Receptor β ( ) Repertoire Diversity Early Post-Transplant for Severe Combined Immunodeficiency (SCID) Predicts Subsequent Failure of Immune Reconstitution
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.406
Abstract: Introduction Development of a diverse T cell repertoire is associated with immune recovery following allogeneic hematopoietic cell transplantation (HCT) for SCID. Although CDR3 spectratyping and staining of Vβ families provide approximations of the diversity of… read more here.
Keywords: diversity; scid; hct; post ... See more keywords
T-cell repertoire analysis and metrics of diversity and clonality.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.07.010
Abstract: The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics. Also, profiling of cellular repertoires in health or disease requires statistical metrics… read more here.
Keywords: cell repertoire; repertoire analysis; diversity; repertoire ... See more keywords