T-cell repertoire analysis and metrics of diversity and clonality.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.07.010
Abstract: The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics. Also, profiling of cellular repertoires in health or disease requires statistical metrics… read more here.
Keywords: cell repertoire; repertoire analysis; diversity; repertoire ... See more keywords
TCR Repertoire Analysis During Therapeutic Interventions in Liver Diseases Using Next‐Generation Sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16835
Abstract: The T cell receptor (TCR) can recognize a vast number of antigens and is closely associated with the pathogenesis of various diseases including autoimmune diseases and malignancies. However, the clinical significance of the TCR repertoire… read more here.
Keywords: liver diseases; tcr repertoire; therapeutic interventions; analysis therapeutic ... See more keywords
Revealing Clonal Responses of Tumor-Reactive T-Cells Through T Cell Receptor Repertoire Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.807696
Abstract: CD8+ T cells are the key effector cells that contribute to the antitumor immune response. They comprise various T-cell clones with diverse antigen-specific T-cell receptors (TCRs). Thus, elucidating the overall antitumor responses of diverse T-cell… read more here.
Keywords: analysis; clonal responses; tcr repertoire; immunology ... See more keywords
Machine Learning Approaches to TCR Repertoire Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.858057
Abstract: Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine… read more here.
Keywords: machine; repertoire analysis; machine learning; immunology ... See more keywords
B cell receptor repertoire analysis from autopsy samples of COVID-19 patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1034978
Abstract: Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being developed world over. We investigated the possibility of producing artificial antibodies from the formalin fixation and paraffin-embedding (FFPE) lung lobes of a… read more here.
Keywords: analysis autopsy; artificial antibodies; repertoire analysis; cell receptor ... See more keywords