Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112268
Abstract: Repetitive mild traumatic brain injuries (TBI) impair cognitive abilities and increase risk of neurodegenerative disorders in humans. We developed two repetitive mild TBI models in rats with different time intervals between successive weight-drop injuries. Rats… read more here.
Keywords: cognitive impairment; injury; brain; repetitive mild ... See more keywords
Examining changes in rodent temperament following repetitive mild traumatic brain injury in adolescence.
Sign Up to like & getrecommendations! Published in 2020 at "Behavioral neuroscience"
DOI: 10.1037/bne0000413
Abstract: Mild traumatic brain injuries are known to cause a host of symptoms, including headaches, nausea, and depression, that when persistent, are known as postconcussive syndrome. In addition to these overt symptomologies, individuals may experience changes… read more here.
Keywords: traumatic brain; mild traumatic; injury; temperament ... See more keywords
Repetitive Mild Closed Head Injury Alters Protein Expression and Dendritic Complexity in a Mouse Model.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurotrauma"
DOI: 10.1089/neu.2017.5070
Abstract: Worldwide head injuries are a growing problem. In the United States alone, 1.7 million people suffer a head injury each year. While most of these injuries are mild, head injury sufferers still sustain symptoms that… read more here.
Keywords: dendritic complexity; head injury; injury; mouse model ... See more keywords
Tau pathology, metal dyshomeostasis and repetitive mild traumatic brain injury: an unexplored link paving the way for neurodegeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurotrauma"
DOI: 10.1089/neu.2021.0241
Abstract: Repetitive mild traumatic brain injury (r-mTBI), commonly experienced by athletes and military personnel, causes changes in multiple intracellular pathways, one of which involves the tau protein. Tau phosphorylation plays a role in several neurodegenerative conditions… read more here.
Keywords: metal dyshomeostasis; pathology; neurodegeneration; repetitive mild ... See more keywords
Optimizing choice and timing of behavioral outcome tests following repetitive mild traumatic brain injury: A machine learning-based approach on multiple preclinical experiments.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0486
Abstract: Repetitive mild traumatic brain injury (rmTBI) is a potentially debilitating condition with long-term sequelae. Animal models are used to study rmTBI in a controlled environment, but there is currently no established standard battery of behavioral… read more here.
Keywords: traumatic brain; outcome; behavioral tests; mild traumatic ... See more keywords
Altered amyloid precursor protein, tau‐regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1 month following repetitive mild traumatic brain injury
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15752
Abstract: Repetitive mild traumatic brain injury, commonly experienced following sports injuries, results in various secondary injury processes and is increasingly recognised as a risk factor for the development of neurodegenerative conditions such as chronic traumatic encephalopathy,… read more here.
Keywords: month; brain; mild traumatic; pathology ... See more keywords
Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-021-01161-2
Abstract: We have previously reported long-term changes in the brains of non-concussed varsity rugby players using magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and functional magnetic imaging (fMRI). Others have reported cognitive deficits in contact… read more here.
Keywords: pathological changes; long term; spectroscopy; injury ... See more keywords
Assessment of behavioral, neuroinflammatory, and histological responses in a model of rat repetitive mild fluid percussion injury at 2 weeks post-injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.945735
Abstract: Repetitive mild traumatic brain injury (rmTBI) is a prominent public health concern, with linkage to debilitating chronic sequelae. Developing reliable and well-characterized preclinical models of rmTBI is imperative in the investigation of the underlying pathophysiological… read more here.
Keywords: mild; repetitive mild; percussion injury; injury ... See more keywords