Articles with "replacement indole" as a keyword



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Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility.

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Published in 2021 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.0c00588

Abstract: Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility.… read more here.

Keywords: indole carboxamides; carboxamides yields; amine replacement; amide amine ... See more keywords