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Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00588
Abstract: Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility.…
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Keywords:
indole carboxamides;
carboxamides yields;
amine replacement;
amide amine ... See more keywords