Mechanisms of Neutralizing Anti-drug Antibody Formation and Clinical Relevance on Therapeutic Efficacy of Enzyme Replacement Therapies in Fabry Disease
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DOI: 10.1007/s40265-021-01621-y
Abstract: Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A (AGAL/GLA) gene. The lysosomal accumulation of the substrates globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) results in progressive renal failure,… read more here.
Keywords: enzyme replacement; fabry disease; disease; neutralizing anti ... See more keywords
Challenges and opportunities when transitioning from in vivo gene replacement to in vivo CRISPR/Cas9 therapies – a spotlight on hemophilia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2090241
Abstract: ABSTRACT Introduction Currently, a few in vivo gene replacement therapies are commercially available, with many in clinical development for the treatment of some inherited monogenic diseases. These disorders arise from mutations in genes encoding essential… read more here.
Keywords: gene replacement; replacement therapies; vivo gene; challenges opportunities ... See more keywords
Harmonizing antibiotic regimens with renal replacement therapy
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DOI: 10.1080/14787210.2020.1764845
Abstract: ABSTRACT Introduction: Critically ill patients with acute kidney injury often require renal replacement therapy and antibiotic therapy. Mortality rates are high in these patients, possibly due to ineffective dosing due to altered pharmacokinetic profiles and… read more here.
Keywords: replacement; replacement therapy; therapy harmonizing; renal replacement ... See more keywords
Common adverse events of electronic cigarettes compared with traditional nicotine replacement therapies: A systematic review and meta-analysis.
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DOI: 10.1111/dar.13674
Abstract: ISSUES Established literature suggests that electronic cigarettes (EC) are more effective than traditional nicotine replacement therapies (NRT) as a smoking cessation aid, but the factors that mediate this difference remain poorly understood. We examine how… read more here.
Keywords: nicotine ecs; ecs; nicotine replacement; replacement therapies ... See more keywords
Ceftaroline and Avibactam Removal by Continuous Renal Replacement Therapies: An in vitro Study.
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DOI: 10.1159/000529264
Abstract: INTRODUCTION Continuous renal replacement therapies (CRRTs) are frequently used in critically ill patients; however, there are scarce in vitro and in vivo studies showing the extracorporeal elimination of ceftaroline and avibactam. The aim of this… read more here.
Keywords: ceftaroline; replacement therapies; renal replacement; ceftaroline avibactam ... See more keywords
Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies
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DOI: 10.3389/fimmu.2023.1107334
Abstract: Background Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Although there are some studies showing links between endocrine and immune systems, the ones concerning hypopituitarism are limited. The… read more here.
Keywords: hypopituitarism; replacement therapies; level; mannan binding ... See more keywords
Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
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DOI: 10.3390/nu13010267
Abstract: Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement… read more here.
Keywords: based management; management inflammaging; nutrition based; renal replacement ... See more keywords