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   Articles with "replicase" as a keyword



Slippage at the initiation of RNA synthesis by Qβ replicase results in a periodic polyG pattern

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14556

Abstract: The repetitive copying of template nucleotides due to transcriptional slippage has not been reported for RNA‐directed RNA polymerases of positive‐strand RNA phages. We unexpectedly observed that, with GTP as the only substrate, Qβ replicase, the… read more here.

Keywords: slippage; replicase; synthesis; initiation rna ... See more keywords

Probing the legitimate initiation of RNA synthesis by Qβ replicase with oligonucleotide primers

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recommendations! Published in 2024 at "FEBS Letters"

DOI: 10.1002/1873-3468.14833

Abstract: Oligoribonucleotides complementary to the template 3′ terminus were tested for their ability to initiate RNA synthesis on legitimate templates capable of exponential amplification by Qβ replicase. Oligonucleotides shorter than the distance to the nearest predicted… read more here.

Keywords: initiation; probing legitimate; rna synthesis; rna ... See more keywords
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Murine norovirus replicase augments RIG-I-like receptors-mediated antiviral interferon response.

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recommendations! Published in 2020 at "Antiviral research"

DOI: 10.1016/j.antiviral.2020.104877

Abstract: Noroviruses are the main causative agents for acute viral gastroenteritis worldwide. RIG-I-like receptors (RLRs) triggered interferon (IFN) activation is essential for host defense against viral infections. In turn, viruses have developed sophisticated strategies to counteract… read more here.

Keywords: response; replicase; interferon; murine norovirus ... See more keywords

Nucleolin interacts with the rabbit hemorrhagic disease virus replicase RdRp, nonstructural proteins p16 and p23, playing a role in virus replication

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recommendations! Published in 2022 at "Virologica Sinica"

DOI: 10.1016/j.virs.2022.01.004

Abstract: Rabbit hemorrhagic disease virus (RHDV) is a member of the Caliciviridae family and cannot be propagated in vitro, which has impeded the progress of investigating its replication mechanism. Construction of an RHDV replicon system has… read more here.

Keywords: rabbit hemorrhagic; rdrp; virus; host ... See more keywords

A four-in-one replicase integrating key enzymatic activities for DNA replication

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf542

Abstract: Abstract DNA replication is a fundamental process in all living organisms. As the most diverse and abundant biological entities on Earth, bacteriophages may utilize unconventional methods for genome replication. In this study, we identified a… read more here.

Keywords: replication; dna replication; primase; replicase ... See more keywords

Live-cell imaging of a plant virus replicase during infection using a genetically encoded, antibody-based probe

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recommendations! Published in 2025 at "Plant Physiology"

DOI: 10.1093/plphys/kiaf240

Abstract: Abstract Replication of plant positive-strand RNA viruses occurs in association with intracellular membranes. To date, no versatile technology has been developed to directly label and visualize an active replicase in live plant cells because, in… read more here.

Keywords: plant; plant virus; infection; replicase ... See more keywords

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

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recommendations! Published in 2021 at "Journal of Virology"

DOI: 10.1128/jvi.00355-21

Abstract: A key element of every virus with an RNA genome is the RNA replicase. Understanding the principles of RNA replicase formation and functioning is therefore crucial for understanding and responding to the emergence of new… read more here.

Keywords: rna replicase; formation; p123; virus ... See more keywords

Co-opting ATP-generating glycolytic enzyme PGK1 phosphoglycerate kinase facilitates the assembly of viral replicase complexes

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recommendations! Published in 2017 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1006689

Abstract: The intricate interactions between viruses and hosts include exploitation of host cells for viral replication by using many cellular resources, metabolites and energy. Tomato bushy stunt virus (TBSV), similar to other (+)RNA viruses, induces major… read more here.

Keywords: replicase complexes; replication compartment; replicase; viral replicase ... See more keywords

Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.828636

Abstract: Hepatitis E virus (HEV) is the major cause of acute hepatitis worldwide. HEV is a positive-sense RNA virus expressing three open reading frames (ORFs). ORF1 encodes the ORF1 non–structural polyprotein, the viral replicase which transcribes… read more here.

Keywords: replication; replicase; hepatitis virus; hev ... See more keywords
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Ribosome Pausing at Inefficient Codons at the End of the Replicase Coding Region Is Important for Hepatitis C Virus Genome Replication

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21186955

Abstract: Hepatitis C virus (HCV) infects liver cells and often causes chronic infection, also leading to liver cirrhosis and cancer. In the cytoplasm, the viral structural and non-structural (NS) proteins are directly translated from the plus… read more here.

Keywords: inefficient codons; genome replication; replicase; hepatitis virus ... See more keywords

The Replicase Protein of Potato Virus X Is Able to Recognize and Trans-Replicate Its RNA Component

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recommendations! Published in 2024 at "Viruses"

DOI: 10.3390/v16101611

Abstract: The trans-replication system explores the concept of separating the viral RNA involved in the translation of the replicase protein from the replication of the viral genome and has been successfully used to study the replication… read more here.

Keywords: replication; potato virus; virus; replicase ... See more keywords