Organization of the Flavivirus RNA replicase complex
Sign Up to like & getrecommendations! Published in 2017 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1437
Abstract: Flaviviruses, such as dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses, are serious human pathogens that cause significant morbidity and mortality globally each year. Flaviviruses are single‐stranded, positive‐sense RNA viruses, and encode two… read more here.
Keywords: rna replicase; flavivirus rna; ns3 ns5; organization flavivirus ... See more keywords
NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006343
Abstract: Hepatitis C virus (HCV) RNA is synthesized by the replicase complex (RC), a macromolecular assembly composed of viral non-structural proteins and cellular co-factors. Inhibitors of the HCV NS5A protein block formation of new RCs but… read more here.
Keywords: hcv; half; ns5a inhibitors; hepatitis virus ... See more keywords